Cdc7 Activators
Cdc7, also known as cell division cycle 7 protein kinase, is a serine/threonine kinase that plays a crucial role in the regulation of cell cycle progression and DNA replication. Its activation is tightly controlled to ensure proper timing and coordination of cellular processes essential for genome stability and faithful transmission of genetic material during cell division. Cdc7 functions primarily by phosphorylating and activating the replicative helicase complex, which unwinds the DNA double helix during DNA replication initiation. This phosphorylation event promotes the assembly of the pre-replicative complex (pre-RC) at origins of DNA replication, facilitating the recruitment and activation of the replicative DNA polymerases necessary for DNA synthesis.
The activation of Cdc7 kinase is intricately regulated throughout the cell cycle, with its activity peaking during the G1/S transition when cells prepare for DNA replication. This activation is mediated by multiple mechanisms, including the binding of Cdc7 to its regulatory subunit, Dbf4, forming an active Cdc7-Dbf4 complex. The activity of this complex is further regulated by phosphorylation and post-translational modifications, as well as by the availability of cofactors and substrates required for its function. Additionally, Cdc7 activity is subject to stringent cell cycle checkpoints and feedback mechanisms that ensure its proper activation and coordination with other cell cycle regulators. Overall, the precise activation of Cdc7 kinase is crucial for the initiation of DNA replication and the maintenance of genome integrity, highlighting its importance in cellular homeostasis and proliferation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine is a nucleoside involved in various cellular processes, including energy transfer as adenosine triphosphate (ATP). It can indirectly activate Cdc7 by influencing the ATP-dependent processes that regulate cell cycle progression. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin, also known as vitamin B2, participates in cellular metabolism. It plays a role in the activation of kinases involved in cell cycle regulation, potentially affecting Cdc7 activation through its impact on intracellular energy and redox status. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium carbonate, a mood stabilizer, can modulate various signaling pathways. It might indirectly activate Cdc7 by influencing the glycogen synthase kinase-3 (GSK-3) pathway, which is connected to cell cycle regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in red grapes. It can activate the AMP-activated protein kinase (AMPK) pathway, potentially influencing Cdc7 activation through the regulation of cellular energy homeostasis and cell cycle control. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic adenosine monophosphate (cAMP). This can influence Cdc7 activation by modulating downstream signaling cascades associated with cell cycle progression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analogue that can influence DNA methylation patterns. Its impact on epigenetic regulation may indirectly activate Cdc7 by modifying the expression of genes involved in cell cycle control. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMPK, a key cellular energy sensor. By activating AMPK, AICAR can modulate cellular processes related to energy balance and cell cycle progression, potentially influencing Cdc7 activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. It can influence chromatin structure and gene expression, potentially activating Cdc7 by modulating the epigenetic regulation of genes involved in cell cycle progression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It can activate the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, potentially influencing Cdc7 activation by regulating oxidative stress and cellular redox status. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX is a glycogen synthase kinase-3 (GSK-3) inhibitor. It can modulate signaling pathways associated with cell cycle regulation, potentially influencing Cdc7 activation through the regulation of GSK-3-dependent processes. | ||||||