Cdc25B Activators
Cdc25B activators belong to a specific class of chemical compounds that play a crucial role in regulating the cell cycle, specifically at the G2 to M transition phase. To understand the significance of Cdc25B activators, it is essential to delve into the molecular mechanisms underlying cell cycle regulation. The cell cycle is a highly coordinated and tightly controlled process that governs the growth, development, and reproduction of all living organisms. It consists of distinct phases, including G1 (gap 1), S (synthesis), G2 (gap 2), and M (mitosis), with checkpoints in place to ensure the fidelity of DNA replication and proper progression.
Cdc25B activators target the Cdc25B phosphatase enzyme, a critical player in the cell cycle regulation. Cdc25B is responsible for dephosphorylating and activating cyclin-dependent kinases (CDKs), thereby promoting cell cycle progression from G2 to M phase. This activation of CDKs is pivotal for the transition into mitosis, where cell division occurs. Cdc25B activators, as the name suggests, stimulate the activity of Cdc25B phosphatase, which, in turn, enhances the activity of CDKs. This heightened CDK activity ensures that the cell cycle proceeds smoothly, facilitating cell division when conditions are favorable and ensuring the integrity of genetic material. In essence, Cdc25B activators act as molecular switches that help orchestrate the precise timing of cell division, a fundamental process in biology and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide can cause DNA damage, which may indirectly lead to increased expression of Cdc25B as part of the cellular response to repair DNA and resume the cell cycle. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
As a topoisomerase inhibitor, camptothecin introduces DNA damage, potentially causing a cellular response that includes the upregulation of cell cycle regulators such as Cdc25B. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
This compound is incorporated into RNA and DNA, which can disrupt normal cell cycle progression and may induce a stress response that alters the expression of genes like Cdc25B. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts, leading to DNA damage and potentially affecting the cell cycle regulation system, which could influence Cdc25B expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, leading to disrupted nucleotide synthesis and potentially affecting cell cycle progression, which may impact Cdc25B expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
It inhibits ribonucleotide reductase, leading to DNA damage responses that could involve changes in Cdc25B expression levels. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
As an anthracycline antibiotic, doxorubicin intercalates DNA and may cause alterations in the expression of cell cycle-related genes, possibly including Cdc25B. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and disrupts normal cell cycle progression, which could lead to changes in the regulation of Cdc25B expression. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
By inhibiting microtubule formation, vinblastine can arrest the cell cycle, potentially affecting Cdc25B expression as a part of the cellular response. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
Thymidine is a nucleoside that, when excessively present, can cause a nucleotide imbalance and DNA replication stress, potentially influencing Cdc25B expression. | ||||||