Cdc14b Phosphatase Activators
Cdc14b Phosphatase Activators constitute a group of compounds that enhance the activity of Cdc14b, a dual-specificity phosphatase involved in various cellular processes like cell cycle regulation and DNA damage response. Okadaic Acid and Calyculin A, both inhibitors of PP1and PP2A, indirectly upregulate the activity of Cdc14b Phosphatase by increasing the phosphorylation levels within the cell and reducing phosphatase competition. This indirect enhancement promotes a greater rate of dephosphorylation of Cdc14b-specific substrates, leading to heightened functional activity of the protein. Similarly, compounds like Sodium Orthovanadate, Fostriecin, Endothall, and Cantharidin disrupt the balance of cellular phosphatase activities, thus favoring the action of Cdc14b. These chemicals achieve this by selectively inhibiting competing phosphatases, consequently allowing Cdc14b a larger array of substrates to dephosphorylate, effectively amplifying its role in the cell.
Further, Tautomycin and Microcystin-LR, through their potent inhibition of PP1 and PP2A, provide an indirect boost to Cdc14b's activity, emphasizing the cellular requirement to maintain phosphorylation homeostasis. Phenylarsine Oxide and Norcantharidin, albeit primarily affecting tyrosine phosphatases, trigger compensatory cellular mechanisms that could augment serine/threonine phosphatase activities, including those of Cdc14b. Beryllium Fluoride and Zinc Chloride, while non-specific in their inhibitory action, potentially facilitate Cdc14b's phosphatase function by altering the pool of phosphorylated substrates available, further tipping the scales in favor of Cdc14b Phosphatase activation. Collectively, these Cdc14b Phosphatase Activators illustrate the intricate interplay within cellular signaling networks, where the inhibition of one set of phosphatases can lead to the indirect activation of another, ensuring that crucial cellular functions carried out by proteins like Cdc14b are robustly regulated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), leading to increased phosphorylation levels within the cell. Inhibition of PP2A can indirectly enhance the activity of Cdc14b Phosphatase by reducing competition for substrates or by affecting the balance of phosphatase activities, thus potentially increasing the dephosphorylation of Cdc14b-specific substrates. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A, similar to Okadaic Acid, is an inhibitor of PP1 and PP2A. By inhibiting these phosphatases, Calyculin A could indirectly increase the activity of Cdc14b Phosphatase, enabling a greater rate of dephosphorylation on Cdc14b-specific substrates within the cell. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate acts as a general inhibitor of protein tyrosine phosphatases. Its action could lead to a compensatory increase in serine/threonine phosphatase activity, such as that of Cdc14b, to maintain cellular phosphorylation balance. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Fostriecin selectively inhibits PP2A over PP1. This selective inhibition may lead to an indirect upregulation of Cdc14b Phosphatase activity by altering phosphatase activity competition and substrate availability within the cell. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Endothall is an inhibitor of PP2A and PP1. By inhibiting these phosphatases, it could indirectly promote the activity of Cdc14b by increasing the pool of substrates available for dephosphorylation by Cdc14b. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin inhibits PP2A and PP1, which may result in an indirect enhancement of Cdc14b Phosphatase function due to reduced competition for phosphatase substrates and a potential rebalancing of cellular phosphatase activities. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide is an inhibitor of protein tyrosine phosphatases. While its primary action is on tyrosine residues, the compensatory cellular response might enhance serine/threonine phosphatase activity, such as Cdc14b's, to adjust the phosphorylation dynamics. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $111.00 | 2 | |
Norcantharidin is a demethylated analog of cantharidin and inhibits PP1 and PP2A. This inhibition could indirectly facilitate the action of Cdc14b Phosphatase by making more substrates available for its activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Chloride can act as a non-specific inhibitor of protein phosphatases. By this action, Zinc Chloride could indirectly increase Cdc14b Phosphatase activity by altering the phosphorylation state within cells and affecting substrate availability for Cdc14b. | ||||||