CD45RC Inhibitors
Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alendronate Sodium Salt Trihydrate | 121268-17-5 | sc-202049 | 100 mg | $180.00 | 2 | |
Alendronate Sodium Salt Trihydrate exhibits unique interactions with bone mineral surfaces, facilitating its role in modulating osteoclast activity. Its tri-hydrate form enhances solubility, promoting effective adsorption onto hydroxyapatite. The compound engages in ionic and hydrogen bonding, influencing the stability of the mineral matrix. This interaction alters the kinetics of bone resorption, showcasing its distinct behavior in biochemical pathways related to bone metabolism. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits protein kinase C (PKC), which is involved in T-cell activation where CD45RC plays a role. By inhibiting PKC, downstream T-cell activation events requiring CD45RC's phosphatase activity are diminished. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit the phosphorylation events necessary for T-cell receptor signaling, where CD45RC is implicated in dephosphorylating specific substrates to modulate T-cell activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases which are upstream of CD45RC. Inhibition of Src kinases can prevent initiation of the signaling cascade that CD45RC is a part of, leading to functional inhibition of CD45RC. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. PI3K is part of the signaling pathway that involves CD45RC during T-cell activation. Inhibition of PI3K leads to reduced T-cell activation and thereby CD45RC function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 also inhibits PI3K, which is involved in the T-cell activation pathway. By inhibiting PI3K, LY294002 can lead to a decrease in T-cell receptor signaling, thus functionally inhibiting CD45RC. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib inhibits multiple tyrosine kinases including Src family kinases, which participate in the signaling pathways where CD45RC is involved. This inhibition can suppress the pathway activity, indirectly inhibiting CD45RC function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits protein tyrosine kinases, which could reduce the phosphorylation necessary for T-cell activation where CD45RC is involved, thus inhibiting CD45RC function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which are part of the MAPK/ERK pathway that interacts with T-cell receptor signaling. By inhibiting MEK, U0126 can indirectly inhibit the signaling pathways involving CD45RC. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK1, which is upstream of the pathways involving CD45RC in T-cell activation. By inhibiting MEK1, PD98059 can result in functional inhibition of CD45RC. | ||||||