Molecular structure of Alendronate Sodium Salt Trihydrate, CAS Number: 121268-17-5
Alendronate Sodium Salt Trihydrate (CAS 121268-17-5)
See product citations (2)
Application:
Alendronate, Sodium Salt is a robust inhibitor of bone resorption that induces apoptosis
CAS Number:
121268-17-5
Purity:
≥99%
Molecular Weight:
325.1
Molecular Formula:
C4H12NNaO7P2•3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Alendronate Sodium Salt Trihydrate is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone reabsorption and induces apoptosis in osteoclasts, among other cell types, by modification of GTP-binding proteins post-transcriptionally. The compound may act to act as a selective inhibitor of FDPS (farnesyl diphosphate synthase). Prostate cancer studies also revealed that Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate Sodium Salt Trihydrate is an inhibitor of CD45RC and MMP.
Alendronate Sodium Salt Trihydrate (CAS 121268-17-5) References
- Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. | Bergstrom, JD., et al. 2000. Arch Biochem Biophys. 373: 231-41. PMID: 10620343
- Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. | Lehenkari, PP., et al. 2002. Mol Pharmacol. 61: 1255-62. PMID: 11961144
- Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | Virtanen, SS., et al. 2002. Cancer Res. 62: 2708-14. PMID: 11980672
- New bone formation with teriparatide [human parathyroid hormone-(1-34)] is not retarded by long-term pretreatment with alendronate, estrogen, or raloxifene in ovariectomized rats. | Ma, YL., et al. 2003. Endocrinology. 144: 2008-15. PMID: 12697709
- An NMR metabolomic study on the effect of alendronate in ovariectomized mice. | Chen, SY., et al. 2014. PLoS One. 9: e106559. PMID: 25184758
- Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase. | Liu, D., et al. 2021. Bioengineered. 12: 1997-2006. PMID: 34024253
- Fabrication of Membrane Sensitive Electrodes for the Validated Electrochemical Quantification of Anti-Osteoporotic Drug Residues in Pharmaceutical Industrial Wastewater. | Abdel-Gawad, SA., et al. 2021. Molecules. 26: PMID: 34443681
Inhibitor of:
CD45RC, FDPS, and MMP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Alendronate Sodium Salt Trihydrate, 100 mg | sc-202049 | 100 mg | $180.00 |