CD34 Activators
CD34 Activators refers to a diverse group of chemical compounds and synthetic molecules that influence the behavior of cells expressing the CD34 glycoprotein, a surface marker commonly associated with hematopoietic stem and progenitor cells. These activators do not necessarily target CD34 directly but can exert their effects through a range of molecular mechanisms that ultimately impact the state or function of CD34+ cells. For example, some compounds bind to receptors co-expressed with CD34, such as FLT3 and c-Kit, thereby modulating intracellular signaling pathways that influence cell proliferation, survival, and differentiation. Others, like histone deacetylase inhibitors, alter the epigenetic landscape of the cell, which in turn may influence the activation and propagation of CD34+ cells. In this way, CD34 Activators span different chemical classes, including but not limited to immunosuppressants, corticosteroids, and kinase inhibitors.
It's also important to note that the concept of "activation" in this context is nuanced. While some compounds may induce cellular proliferation, others might promote cellular quiescence or direct differentiation into specific lineages. Some compounds are known to maintain the 'stemness' of CD34+ cells, thereby inhibiting their differentiation and extending their lifespan in a cultured setting. Meanwhile, others stimulate these cells to differentiate into various blood cell lineages, effectively reducing their stem cell characteristics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
This immunosuppressive drug inhibits calcineurin, affecting T-cell activation. In the context of CD34+ cells, it has been shown to induce the expansion of these cells in some studies, possibly by affecting the cellular environment. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Known for its effects on the nervous system, it also acts as a histone deacetylase (HDAC) inhibitor, which can lead to the chromatin remodeling required for the activation and proliferation of CD34+ cells. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
This compound has been found to inhibit the maturation of CD34+ progenitor cells to megakaryocytes, thereby potentially preserving the stemness of these cells. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a short-chain fatty acid and HDAC inhibitor, it can affect chromatin structure and gene expression in CD34+ cells, possibly promoting their expansion or directing their differentiation. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
A Rho-associated protein kinase (ROCK) inhibitor that improves the survival and adhesion of CD34+ cells in culture, thus supporting their expansion and maintenance. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of Vitamin B3 that acts as an HDAC inhibitor and a SIRT1 inhibitor, supporting the ex vivo expansion of CD34+ cells and potentially blocking their differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, it could affect the metabolism and function of CD34+ cells, possibly promoting quiescence or altering differentiation pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This corticosteroid modulates various signaling pathways and has been used in some protocols to direct the differentiation of CD34+ cells into specific lineages, such as lymphoid cells. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Similar to dexamethasone, it is used in culture conditions to modulate the cellular environment for CD34+ cells, often promoting the expansion of specific cell types. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
As a PKC activator, PMA can induce cellular activation and has been used in studies to stimulate differentiation in CD34+ cells, particularly into myeloid lineages. | ||||||