Date published: 2025-12-11

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CD34 Inhibitors

CD34 Inhibitors comprise a group of small molecules that exhibit the ability to interfere with the activity of CD34, a cell surface glycoprotein predominantly found on hematopoietic stem cells and endothelial progenitor cells. CD34 plays a pivotal role in various physiological processes, including hematopoiesis, vasculogenesis, and tissue repair, by facilitating cell adhesion, migration, and signaling. CD34+ cells are involved in the maintenance and regeneration of blood and vascular tissues. Inhibitors belonging to this class are designed to modulate the function of CD34, either directly or indirectly, to gain insights into the underlying cellular processes or to investigate their roles in experimental settings. Chemically, CD34 inhibitors can vary widely, encompassing compounds with diverse structures and mechanisms of action. Some CD34 inhibitors target the CD34 protein itself, impeding its function in cell adhesion and signaling. Others may affect downstream signaling pathways associated with CD34, disrupting processes like cell proliferation, migration, and differentiation.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$25.00
$117.00
$209.00
27
(1)

Imatinib inhibits CD34 indirectly by targeting the BCR-ABL fusion protein.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$150.00
$920.00
5
(0)

Sunitinib is a multi-targeted kinase inhibitor that can indirectly inhibit CD34+ cells by disrupting angiogenesis and stromal support.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Dasatinib is primarily used to inhibit BCR-ABL kinase activity in CML, indirectly affecting CD34+ cells by targeting this oncogenic protein.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$205.00
$405.00
9
(1)

Nilotinib targets the BCR-ABL fusion protein, often expressed in CD34+ cells associated with CML, indirectly inhibiting CD34+ leukemia cells.

AP 24534

943319-70-8sc-362710
sc-362710A
10 mg
50 mg
$172.00
$964.00
2
(1)

Ponatinib is a tyrosine kinase inhibitor effective against BCR-ABL, including the T315I mutation, indirectly inhibiting CD34+ leukemia cells by targeting this oncogenic protein.

PKC-412

120685-11-2sc-200691
sc-200691A
1 mg
5 mg
$51.00
$112.00
10
(1)

Midostaurin is a multi-kinase inhibitor that indirectly impacts CD34+ cells by inhibiting the proliferation of leukemic cells.

Regorafenib

755037-03-7sc-477163
sc-477163A
25 mg
50 mg
$320.00
$430.00
3
(0)

Regorafenib is a multi-kinase inhibitor that indirectly inhibits CD34+ cells by targeting various receptors involved in angiogenesis and tumor growth.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Sorafenib inhibits multiple kinases, including RAF kinases, VEGFR, and PDGFR, indirectly affecting CD34+ cells by disrupting angiogenesis and the tumor microenvironment.

Cediranib

288383-20-0sc-483599
sc-483599A
sc-483599B
5 mg
10 mg
25 mg
$137.00
$220.00
$406.00
(0)

Cediranib is a VEGFR inhibitor that indirectly impacts CD34+ cells by inhibiting angiogenesis, which is essential for the survival and growth of tumor-associated CD34+ cells.

XL-184 free base

849217-68-1sc-364657
sc-364657A
5 mg
10 mg
$92.00
$204.00
1
(1)

Cabozantinib is a multi-kinase inhibitor that indirectly inhibits CD34+ cells in certain malignancies by disrupting the tumor microenvironment.