CD1B3 Activators
Chemical activators of CD1B3 enhance its antigen-presenting function by facilitating its translocation to the cell surface. Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 are both activators of protein kinase C (PKC), a key player in the activation of CD1B3. Through the activation of PKC, these chemicals promote the movement of CD1B3 to the cell membrane, enabling it to present lipid antigens more effectively. Similarly, Ionomycin raises intracellular calcium levels, which in turn activate PKC and subsequently CD1B3, supporting its translocation to the cell surface. Prostratin, another non-tumor-promoting phorbol ester, activates PKC, leading to an increase in the surface expression of CD1B3.
Furthermore, Ingenol Mebutate and 1,2-Dioctanoyl-sn-glycerol (DiC8), by their action on PKC, can also encourage the translocation and activation of CD1B3 on the cell surface. Phorbol 12,13-dibutyrate (PDBu) and 4α-Phorbol are additional phorbol esters that activate PKC, which is instrumental in the trafficking of CD1B3 to the cell membrane. Teleocidin B-4, a natural product, and Indolactam V, are compounds that activate PKC, thus enhancing CD1B3 cell surface expression and function. Lastly, OAG (1-Oleoyl-2-acetyl-sn-glycerol) is a diacylglycerol analog that activates PKC, thereby stimulating the translocation and functional activation of CD1B3, which is crucial for its role in the immune response. Each of these chemicals, by modulating PKC activity, can support the function of CD1B3 in antigen presentation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can lead to the activation of CD1B3 by promoting the translocation of the protein to the cell surface. PKC is known to phosphorylate proteins involved in vesicle trafficking, which can enhance the presentation of lipid antigens by CD1B3. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a PKC activator that can indirectly activate CD1B3. Similar to PMA, Bryostatin 1 leads to the activation of PKC which plays a role in the translocation of CD1B3 to the cell surface, thereby facilitating its antigen-presenting function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate PKC. The activation of PKC, in turn, can promote the translocation of CD1B3 to the cell surface, thus enhancing its activity. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin is a non-tumor-promoting phorbol ester that can activate PKC. The activation of PKC by Prostratin can result in the enhanced surface expression of CD1B3, thereby increasing its lipid antigen-presenting activity. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic diacylglycerol (DAG) analog that can stimulate PKC. By activating PKC, DiC8 can promote the translocation and activation of CD1B3 on the cell surface, which is essential for its antigen-presenting function. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PDBu is a phorbol ester that can activate PKC. Activation of PKC by PDBu can facilitate the translocation of CD1B3 to the cell surface, thereby increasing its ability to present lipid antigens. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
4α-Phorbol is a phorbol ester that can act as a PKC activator, thus it can indirectly activate CD1B3 by enhancing the translocation of the protein to the cell surface to participate in antigen presentation. | ||||||
(−)-Indolactam V | 90365-57-4 | sc-202182 sc-202182A | 300 µg 1 mg | $175.00 $350.00 | 1 | |
Indolactam V is a PKC activator, and by stimulating PKC, it can lead to the activation of CD1B3 through improved trafficking and cell surface expression, which is critical for its role in lipid antigen presentation. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $119.00 $453.00 | 1 | |
OAG is a DAG analog that activates PKC. Through PKC activation, OAG can stimulate the translocation and functional activation of CD1B3 on the cell surface, which is necessary for its antigen-presenting activity. | ||||||