CD13 Activators
CD13 Activators refer to a class of chemical compounds that interact with and modulate the activity of the CD13 enzyme, also known as aminopeptidase N (APN). CD13, a zinc-dependent metalloprotease, is a cell surface glycoprotein found in various tissues and cell types, including immune cells, endothelial cells, and epithelial cells. Its primary function is to cleave amino-terminal amino acids from peptides and proteins, playing a crucial role in the regulation of peptide signaling and processing. CD13 Activators, which can be synthetic or naturally occurring compounds, exert their influence on CD13's enzymatic activity, resulting in alterations of peptide metabolism and cellular responses.
These activators typically interact with CD13 by binding to its active site or modulating its enzymatic activity indirectly through conformational changes. Some CD13 Activators act as substrates for the enzyme, competing with natural substrates and leading to the alteration of peptide profiles in the surrounding environment. Others may influence the enzyme's function by enhancing or inhibiting its catalytic activity, thereby impacting processes such as peptide degradation and receptor signaling. The ability to regulate CD13 activity is of interest in various scientific contexts, as it may have implications for understanding cellular functions, including immune responses, angiogenesis, and peptide-mediated signaling events. By modulating CD13 activity, these compounds provide valuable tools for researchers aiming to decipher the intricate roles of CD13 in normal physiological processes and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a chemical analog of cytidine, a nucleoside present in DNA and RNA. It can be incorporated into DNA and RNA, leading to alterations in gene expression. Studies have suggested that it has the potential to increase CD13 expression, possibly through changes in DNA methylation patterns. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that is known to act as a histone deacetylase inhibitor, modifying the chromatin structure and influencing gene expression. It has been reported to induce CD13 expression in certain cell types, potentially via changes in histone acetylation and transcriptional activation. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is a polar aprotic solvent used in various biological and chemical applications. It has been observed to modulate the expression of various genes, including CD13, potentially due to its effects on cellular permeability and signal transduction pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C, a family of enzymes that play crucial roles in cell signal transduction. PMA has been shown to increase CD13 expression in certain cell types, potentially via the activation of protein kinase C and subsequent signaling pathways. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol is a form of estrogen, a steroid hormone involved in the regulation of the reproductive system. Unlike the broader category of estrogens, β-Estradiol has been specifically linked to modulating CD13 expression, possibly as part of its role in cell growth and differentiation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive activities. It has been shown to influence CD13 expression in certain cell types, potentially through its effects on nuclear factor-kappa B (NF-κB) and other transcription factors. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid is a metabolite of vitamin A that plays a key role in cell growth, differentiation, and apoptosis. It has been reported to induce CD13 expression in certain cell types, potentially contributing to its function in cellular development and differentiation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a member of the thiazolidinedione class of chemicals and acts as an insulin sensitizer. It has been observed to modulate CD13 expression, potentially through its effects on peroxisome proliferator-activated receptor gamma (PPARγ) and related signaling pathways. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide is a compound with diverse biological effects, including the induction of cell differentiation and apoptosis. It has been reported to increase CD13 expression in certain cell types, potentially as part of its role in inducing cellular differentiation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound found in turmeric, known for its anti-inflammatory and antioxidant properties. Studies have suggested that curcumin can modulate CD13 expression, potentially through its effects on nuclear factor-kappa B (NF-κB) and other signaling pathways. | ||||||