CD101 Activators
CD101 activators are a suite of chemical compounds that indirectly enhance the functional activity of CD101 through a variety of signaling mechanisms. Forskolin, Prostaglandin E2, Rolipram, BAY 60-7550, and Zaprinast all work to elevate intracellular cAMP levels, leading to the activation of PKA, which is known to phosphorylate substrates that influence the activity of CD101, particularly within the context of immune cell regulation. Isoproterenol, through the activation of beta-adrenergic receptors, and 8-Bromo-cAMP, as a direct cAMP analog, serve to bypass typical receptor-mediated pathways to achieve a similar upregulation of PKA activity. This heightened PKA activity can then modulate immune responses where CD101 is a critical component, enhancing its functional role in processes such as T-cell activation and regulatory functions.
Additionally, Ionomycin and A23187, as calcium ionophores, induce an increase in intracellular calcium levels, activating calcium-dependent signaling pathways that could in turn potentiate the function of CD101 in the immune system. PMA, as a PKC activator, targets another arm of signaling that influences CD101 by phosphorylating intermediates involved in immune response regulation. Anisomycin's role in activating stress-activated protein kinases (SAPKs) suggests a potential for influencing immune signaling pathways that enhance CD101 activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, elevating cAMP levels, which in turn activates protein kinase A (PKA). PKA phosphorylates substrates that could specifically enhance the signaling and functional activity of CD101, particularly in immune cells. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 engages EP2 and EP4 receptors to increase cAMP, which activates PKA. This downstream effect is likely to enhance CD101's role in immune modulation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a PDE4 inhibitor, preventing cAMP breakdown, which subsequently increases PKA activity. This could lead to an enhancement of CD101's signaling in immune functions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels, activating calcium-dependent proteins that could potentiate CD101 activity by influencing immune cell signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC, which could phosphorylate proteins in signaling pathways that enhance CD101's activity in immune response regulation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic receptor agonist, increases cAMP levels, thereby activating PKA, which could amplify CD101 signaling pathways involved in immune cell functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, as a calcium ionophore, can indirectly enhance CD101 activity by increasing intracellular calcium and activating downstream signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast, by inhibiting PDE5, increases cAMP levels and could boost PKA activity, leading to enhanced signaling pathways wherein CD101 is active. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs), which could modify immune response pathways that involve CD101 activity enhancement. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP, a synthetic cAMP analog, raises cAMP levels, which can increase PKA activity, leading to potential upregulation of CD101 signaling functions. | ||||||