Ccr1l1 Activators
Ccr1l1, encoding the C-C motif chemokine receptor 1 like 1, is implicated in diverse cellular processes, including positive regulation of the ERK1 and ERK2 cascade, monocyte chemotaxis, and osteoclast differentiation. Predicted to enable C-C chemokine binding, C-C chemokine receptor activity, and phosphatidylinositol phospholipase C activity, Ccr1l1 is located in the plasma membrane, active in the cytoplasm and external side of the plasma membrane. Activation of Ccr1l1 involves a network of chemical modulators that directly or indirectly impact its functions. PMA stimulates PKC, enhancing Ccr1l1 phosphorylation and activities crucial for immune responses. U0126 indirectly activates Ccr1l1 by inhibiting the MAPK pathway, highlighting the importance of MAPK signaling in modulating chemokine receptor activities. Ionomycin induces calcium influx, positively influencing phosphatidylinositol phospholipase C and Ccr1l1 functions. Thapsigargin activates Ccr1l1 through ER stress induction, emphasizing the link between cellular stress responses and chemokine receptor activation.
LY294002 and Wortmannin modulate Ccr1l1 indirectly by suppressing PI3K/Akt signaling, underscoring the interplay between this pathway and Ccr1l1-mediated immune responses. H89, W7, and Gö6976 target PKA, calmodulin, and PKC, respectively, influencing Ccr1l1 functions and emphasizing the regulatory role of these kinases in chemokine receptor activation. Bisindolylmaleimide I and 4α-PMA highlight the importance of PKC isoforms in modulating Ccr1l1-mediated immune responses. Calcium Ionophore A23187 induces intracellular calcium influx, positively impacting Ccr1l1 and emphasizing the significance of calcium signaling in regulating chemokine receptor activities. In summary, the intricate network of chemical activators reveals the complexity of Ccr1l1 activation and its involvement in immune responses and cellular processes. Understanding the specific pathways and molecules influenced by these chemicals provides insights into the regulatory mechanisms governing Ccr1l1 function, paving the way for further exploration of its role in health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Ccr1l1 by stimulating PKC, a downstream effector. Activated PKC enhances Ccr1l1 phosphorylation, promoting its chemokine binding and receptor activities. This triggers positive regulation of the ERK1 and ERK2 cascade, monocyte chemotaxis, and osteoclast differentiation, crucial for immune responses and bone metabolism. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK inhibitor, indirectly activates Ccr1l1 by inhibiting the MAPK pathway. Reduced ERK1 and ERK2 cascade activity leads to upregulated Ccr1l1 functions, including enhanced C-C chemokine binding and chemotaxis. This highlights the pivotal role of MAPK signaling in modulating Ccr1l1 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, a calcium ionophore, activates Ccr1l1 by inducing intracellular calcium influx. Increased calcium levels stimulate phosphatidylinositol phospholipase C, positively impacting Ccr1l1 function. This activation plays a crucial role in Ccr1l1-mediated signal transduction, emphasizing the significance of calcium signaling in regulating chemokine receptor activities. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin activates Ccr1l1 through endoplasmic reticulum stress induction. ER stress enhances phosphatidylinositol phospholipase C activity, positively influencing Ccr1l1 function. This highlights the intricate connection between cellular stress responses and Ccr1l1 activation, emphasizing the role of ER homeostasis in modulating chemokine receptor activities. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly activates Ccr1l1 by suppressing PI3K/Akt signaling. Inhibition of this pathway positively impacts Ccr1l1 expression and function, contributing to positive regulation of monocyte chemotaxis. This emphasizes the cross-talk between PI3K/Akt signaling and Ccr1l1-mediated immune responses. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W7, a calmodulin antagonist, activates Ccr1l1 by inhibiting calmodulin. Reduced calmodulin activity positively impacts phosphatidylinositol phospholipase C, enhancing Ccr1l1 chemokine binding and receptor activities. This underscores the intricate role of calcium-calmodulin signaling in modulating Ccr1l1 function, emphasizing the importance of calcium-dependent pathways in chemokine receptor activation. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976, a PKC inhibitor, indirectly activates Ccr1l1 by suppressing PKC activity. Inhibition of PKC positively influences Ccr1l1 functions, including positive regulation of the ERK1 and ERK2 cascade. This highlights the regulatory role of PKC in modulating Ccr1l1-mediated signal transduction, underscoring the significance of PKC-dependent pathways in chemokine receptor activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I, a broad-spectrum PKC inhibitor, activates Ccr1l1 by inhibiting PKC isoforms. Suppression of PKC positively influences Ccr1l1 phosphorylation and chemokine binding activity, contributing to positive regulation of monocyte chemotaxis. This underscores the role of PKC isoforms in modulating Ccr1l1-mediated immune responses, emphasizing the complexity of PKC-dependent pathways in chemokine receptor activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, indirectly activates Ccr1l1 by modulating PI3K/Akt signaling. Inhibition of this pathway positively impacts Ccr1l1 expression, contributing to positive regulation of osteoclast differentiation. This highlights the interplay between PI3K/Akt signaling and Ccr1l1-mediated cellular processes, emphasizing the importance of PI3K-dependent pathways in chemokine receptor activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium Ionophore A23187 activates Ccr1l1 by inducing intracellular calcium influx. Increased calcium levels stimulate phosphatidylinositol phospholipase C, positively impacting Ccr1l1 function. This activation plays a crucial role in Ccr1l1-mediated signal transduction, emphasizing the significance of calcium signaling in regulating chemokine receptor activities. | ||||||