CCNI2 Activators
CCNI2, a member of the cyclin family, plays an essential role in cell cycle regulation. The functional activity of CCNI2 can be enhanced through several biochemical mechanisms, primarily involving alterations in intracellular signaling molecules and pathways. For instance, the direct stimulation of adenylyl cyclase by certain compounds elevates cyclic AMP levels within the cell, which can promote the association of CCNI2 with cyclin-dependent kinases (CDKs) to drive the cell cycle. Additionally, activators of protein kinase C (PKC) can phosphorylate target proteins related to cell cycle progression, potentially stabilizing CCNI2 or facilitating its interaction with CDKs. Adrenergic receptor agonists also contribute to CCNI2 activation by increasing intracellular cAMP through adenylyl cyclase activation, further implicating cAMP-dependent pathways in modulating CCNI2's role in cell cycle control.
Other mechanisms include the inhibition of phosphodiesterases, leading to the prevention of cAMP and cGMP degradation, thereby maintaining elevated levels of these signaling molecules that can modulate CCNI2 activity. Inhibition of protein phosphatases, such as with specific toxins, results in an accumulation of phosphorylated proteins, which can indirectly enhance CCNI2's activity through changes in its phosphorylation state. Stress response pathways are also involved, where inhibitors of protein synthesis activate stress-activated protein kinases, which in turn can upregulate CCNI2's activity. Furthermore, compounds that inhibit key enzymes like GSK-3 indirectly influence cell cycle dynamics, thus potentially increasing CCNI2's functional role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate target proteins that are involved in cell cycle progression, potentially resulting in the enhanced activity of CCNI2 by promoting its stability or its interaction with CDKs. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Binds to adrenergic receptors, which can activate adenylyl cyclase and subsequently increase intracellular cAMP levels, potentially enhancing CCNI2 activity via the cAMP-dependent pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine that activates beta-adrenergic receptors, leading to the activation of adenylyl cyclase and an increase in cAMP, which could enhance CCNI2 activity through cAMP-mediated signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, preventing the degradation of cAMP and cGMP, thereby potentially increasing CCNI2 activity through elevated levels of these signaling molecules. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
An inhibitor of phosphatases, which could lead to the accumulation of phosphorylated proteins, indirectly increasing the functional activity of CCNI2 through enhanced phosphorylation states. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, leading to an increase in phosphorylated proteins, which could indirectly increase CCNI2 activity by affecting its phosphorylation status. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits protein synthesis and activates stress-activated protein kinases, which could indirectly upregulate the activity of CCNI2 through stress-response signaling pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase-3 (GSK-3), which could lead to alterations in the cell cycle and indirectly increase the functional activity of CCNI2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Modulates gene expression through retinoic acid receptors, which could lead to changes in cell cycle dynamics and thus indirectly influence the activity of CCNI2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A selective inhibitor of phosphodiesterase 4, which increases cAMP levels, potentially leading to altered cell cycle progression and increased activity of CCNI2. | ||||||