CCL23 Activators
CCL23 activators exert their influence on the pathways that regulate the expression and activity of CCL23. The activators primarily function through the modulation of NF-κB signaling, a key regulatory pathway that controls the transcription of numerous genes, including those coding for chemokines like CCL23. This modulation can be either through direct activation of the pathway, such as through the engagement of TLR4 by LPS or the activation of PKC by PMA, or through the induction of cellular stress responses, like the oxidative stress generated by hydrogen peroxide.
These compounds often have a broader range of functions, with the capacity to influence a variety of signaling cascades within the cell. For instance, glucocorticoids have complex effects on NF-κB signaling and can modulate the immune response in a context-dependent manner. Similarly, anti-inflammatory agents like sulfasalazine and aspirin can lead to compensatory increases in the expression of certain NF-κB regulated genes, including CCL23, under specific conditions. Antioxidants such as resveratrol and curcumin also modulate NF-κB activity, thereby altering CCL23 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
A component of the outer membrane of Gram-negative bacteria that activates toll-like receptor 4 (TLR4), leading to the activation of the NF-κB pathway, which can induce the expression of CCL23 in immune cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol and potent tumor promoter that activates protein kinase C (PKC), leading to the activation of the NF-κB pathway, which is known to upregulate the expression of various chemokines, including CCL23. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
An anti-inflammatory drug that can inhibit NF-κB, paradoxically leading to compensatory mechanisms in certain cellular contexts that upregulate the expression of chemokines such as CCL23. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
An agent that induces oxidative stress, leading to the activation of several transcription factors including NF-κB, which may result in increased expression of CCL23 in response to oxidative stimuli. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An inhibitor of NF-κB activation that can lead to altered cytokine production profiles and may indirectly affect CCL23 expression under certain conditions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
An antioxidant that can modulate NF-κB activity and potentially affect the expression of CCL23 by modulating the cellular redox state. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound found in turmeric with anti-inflammatory properties that can downregulate NF-κB activity, potentially affecting CCL23 expression in a compensatory response to inflammatory inhibition. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $811.00 | ||
An IL-1 receptor antagonist that may modulate the NF-κB pathway and could influence the expression of CCL23 by altering the cellular response to IL-1. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Can modulate the NF-κB pathway and influence the expression of CCL23 indirectly through its anti-inflammatory actions. | ||||||