CCL15 Inhibitors
CCL15 inhibitors are chemical compounds that interact with the chemokine CCL15, also known as leukotactin-1 or MIP-5, which is a member of the chemokine family of signaling proteins. Chemokines like CCL15 play crucial roles in modulating immune cell movement and responses by binding to specific G-protein-coupled receptors (GPCRs) on the surface of target cells. CCL15 is primarily involved in the recruitment and activation of immune cells such as monocytes, lymphocytes, and neutrophils. It is expressed in various tissues, including those affected by inflammation, and influences processes like cellular migration and adhesion. Inhibitors targeting CCL15 work by preventing its interaction with its corresponding receptors, typically CCR1 and CCR3, thus modulating the biological activities triggered by this chemokine.
The chemical structures of CCL15 inhibitors can vary widely, but they often share specific characteristics that allow them to selectively block the binding of CCL15 to its receptors. These inhibitors may be small molecules, peptides, or other types of chemical entities that are designed to disrupt chemokine-receptor interactions through direct binding or by altering the receptor's structure. By inhibiting CCL15, these compounds can potentially regulate complex signaling cascades involved in cellular communication and immune system regulation. The design and optimization of CCL15 inhibitors involve understanding the detailed molecular interactions between the chemokine and its receptor, which can include factors like binding affinity, specificity, and stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may decrease CCL15 expression by activating glucocorticoid receptors, which then interact with specific DNA regions to suppress the transcription of inflammatory cytokine genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could downregulate CCL15 by inhibiting the activation of NF-κB, a transcription factor directly involved in the initiation of CCL15 gene transcription in response to inflammatory stimuli. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may reduce CCL15 levels by hindering the NF-κB-mediated signaling pathway, which is typically activated during the inflammatory response and is known to upregulate the expression of CCL15. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate might lead to decreased CCL15 expression by attenuating the activity of NF-κB and other signaling pathways implicated in the inflammatory response and subsequent chemokine production. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin could downregulate CCL15 expression by blocking cyclooxygenase enzymes, which results in a decrease in prostaglandin synthesis, thereby limiting the inflammatory cascade that would otherwise elevate CCL15 levels. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone is likely to reduce CCL15 expression via the activation of glucocorticoid receptors, which suppress pro-inflammatory cytokine production through transcriptional repression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 may decrease CCL15 expression by binding to BET bromodomains, dislodging chromatin modifying proteins from specific gene promoters and leading to reduced transcriptional activity of the CCL15 gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could inhibit CCL15 by obstructing the mTOR signaling pathway, which plays a crucial role in the translation of proteins involved in cell growth, survival, and cytokine production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may lead to reduced CCL15 expression by inhibiting histone deacetylase activity, thereby increasing acetylation of histones associated with the CCL15 gene and altering gene expression patterns. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 might inhibit the expression of CCL15 by blocking the phosphorylation of IκBα, an inhibitor of NF-κB, thus preventing the translocation of NF-κB to the nucleus and its binding to DNA. | ||||||