CCDC94 Activators
CCDC94 function by modulating the intracellular levels of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). Forskolin directly stimulates adenylate cyclase, the enzyme responsible for the synthesis of cAMP from ATP, leading to an upsurge in intracellular cAMP levels. This surge in cAMP activates PKA, which then phosphorylates CCDC94, leading to its functional activation. Similarly, Isoproterenol, a beta-adrenergic agonist, and Terbutaline, a beta2-adrenergic agonist, also promote the activation of adenylate cyclase, subsequently increasing cAMP and activating PKA, which is known to phosphorylate CCDC94. Prostaglandin E1 (PGE1) engages with its receptor to activate adenylate cyclase, thereby elevating cAMP levels and facilitating the activation of PKA; this series of events also culminates in the activation of CCDC94.
IBMX, Rolipram, and Anagrelide act as inhibitors of different phosphodiesterases, enzymes that degrade cAMP, thereby preventing the decrease of cAMP within the cell and ensuring sustained activation of PKA. This persistent activation of PKA can result in the continuous phosphorylation of CCDC94. Dibutyryl-cAMP and 8-Br-cAMP are cell-permeable cAMP analogs that can cross the cell membrane and directly activate PKA without the need for upstream activation of adenylate cyclase. Cilostazol, a specific phosphodiesterase 3 inhibitor, also raises cAMP levels to support the activation of PKA, subsequently leading to the activation of CCDC94. Dopamine, through its action on D1-like receptors, can trigger adenylate cyclase activity, increasing cAMP levels, and promoting PKA-mediated CCDC94 activation. These chemical activators, through their varied mechanisms of action, ensure the activation of PKA and the subsequent phosphorylation and activation of the protein CCDC94.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases intracellular cAMP levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate CCDC94, leading to its functional activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. By preventing cAMP degradation, IBMX indirectly increases PKA activity, potentially resulting in the functional activation of CCDC94. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that directly activates PKA. Activation of PKA can lead to phosphorylation and functional activation of CCDC94. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cAMP analog that activates PKA. PKA activation may result in the phosphorylation and subsequent functional activation of CCDC94. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to an increase in cAMP levels. Higher cAMP levels enhance PKA activity, which could phosphorylate and activate CCDC94. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylate cyclase, leading to increased production of cAMP and activation of PKA. PKA can then phosphorylate and functionally activate CCDC94. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 (PGE1) increases intracellular cAMP by activating adenylate cyclase through its receptor EP2/EP4. The rise in cAMP levels can enhance PKA activity, which may result in the functional activation of CCDC94. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide is a phosphodiesterase inhibitor that increases cAMP levels, which in turn can activate PKA. PKA-mediated phosphorylation of CCDC94 may lead to its functional activation. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a phosphodiesterase 3 inhibitor which raises intracellular cAMP, enhancing PKA activation. PKA can phosphorylate and activate CCDC94. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can stimulate adenylate cyclase via D1-like receptors, leading to an increase in cAMP and subsequent activation of PKA. PKA can then phosphorylate and functionally activate CCDC94. | ||||||