Date published: 2026-2-14

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CCDC129 Inhibitors

CCDC129 inhibitors encompass a chemical class designed to target the protein encoded by the Coil-Coiled Domain Containing 129 (CCDC129) gene. These inhibitors interact with the protein at a molecular level, obstructing its normal function within cellular processes. The CCDC129 protein typically plays a role in cellular structure and function, potentially involving the regulation of gene expression or the modulation of signal transduction pathways. Inhibitors targeting CCDC129 would, therefore, be expected to interfere with these processes. The exact mechanisms by which CCDC129 contributes to cellular function are not fully elucidated, but inhibitors in this class would likely be designed to bind to the protein's coiled-coil domain, a structural motif involved in protein-protein interactions. By doing so, these inhibitors would prevent CCDC129 from forming functional complexes with other proteins, thereby hindering its ability to carry out its normal biological roles. The chemical compounds that fall under the category of CCDC129 inhibitors would be characterized by their specificity in binding to the CCDC129 protein. This specificity is crucial, as it ensures that the inhibitors do not inadvertently affect other proteins with similar domains or functions. The design of CCDC129 inhibitors would be based on the understanding of the protein's structure, especially the coiled-coil domain that these compounds aim to target. Successful inhibition of CCDC129 could affect various downstream pathways that are regulated by the protein, leading to alterations in gene expression patterns or the disruption of signaling cascades that CCDC129 may be involved in. As research progresses, the specific biochemical pathways modulated by CCDC129 are expected to become clearer, which would, in turn, refine the development of these inhibitors to ensure they effectively achieve their intended purpose without off-target effects.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Staurosporine is a potent kinase inhibitor, which can interfere with various kinases that phosphorylate CCDC129. Phosphorylation is critical for the functional regulation of many proteins, hence, staurosporine indirectly inhibits CCDC129 function by preventing its phosphorylation.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor that blocks the PI3K/AKT signaling pathway. Since PI3K can regulate protein function through various downstream targets, inhibition of this pathway can result in reduced phosphorylation and activation of proteins such as CCDC129.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin specifically inhibits mTOR (mammalian target of rapamycin), which is part of the mTOR signaling pathway involved in cell growth and protein synthesis. Inhibition of mTOR can lead to a decrease in the overall protein synthesis rate, potentially reducing the levels of CCDC129.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is a MEK inhibitor that disrupts the MAPK/ERK pathway. Since the MAPK/ERK pathway can modulate various cellular functions, including protein expression and activity, the inhibition of this pathway may indirectly decrease the activity of CCDC129.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor. The p38 MAPK pathway is implicated in the regulation of protein synthesis and modification. Its inhibition can lead to decreased activation of proteins that are regulated by this pathway, including potentially CCDC129.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is another PI3K inhibitor similar to LY294002, and it acts by inhibiting the AKT signaling pathway. By blocking this pathway, the phosphorylation and subsequent activation of proteins involved in this pathway, such as CCDC129, can be indirectly inhibited.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 can reduce the activation of downstream proteins in this pathway, potentially leading to a decrease in the functional activity of CCDC129.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), part of the MAPK signaling pathways. Inhibition of JNK affects the phosphorylation state of target proteins, which could include CCDC129, thereby decreasing its activity.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib is a proteasome inhibitor that can prevent the degradation of regulatory proteins that control the cell cycle, apoptosis, and other critical cellular processes. This can result in the altered regulation of proteins like CCDC129.

ZM-447439

331771-20-1sc-200696
sc-200696A
1 mg
10 mg
$153.00
$356.00
15
(1)

ZM-447439 is an Aurora kinase inhibitor, which interferes with the cell cycle and division. Aurora kinases can phosphorylate various substrates, and their inhibition may reduce the phosphorylation and activity of proteins like CCDC129.