CCDC128 Inhibitors
Chemical inhibitors of CCDC128 act by disrupting various signaling pathways and cellular processes that are crucial for the protein's activity. Wortmannin and LY294002 target the phosphoinositide 3-kinases (PI3K) pathway, a pathway that is essential for multiple cellular functions, including those related to CCDC128's role in membrane trafficking. By inhibiting PI3K, these chemicals suppress the downstream signaling that could be necessary for CCDC128 to carry out its functions effectively. Staurosporine, a broad-spectrum kinase inhibitor, can inhibit a range of kinases, potentially including those that directly modify CCDC128 through phosphorylation, an essential post-translational modification that often regulates protein function. U0126 and PD98059 are both inhibitors of MEK, which is an upstream activator of ERK. These inhibitors can decrease ERK activation, interfering with signaling pathways involving CCDC128, assuming it has a role in ERK-mediated processes.
Further affecting CCDC128, SB203580 and SP600125 specifically inhibit p38 MAP kinase and c-Jun N-terminal kinase (JNK), respectively. These kinases are part of stress response and various cellular processes, which CCDC128 may be involved in. Inhibition by these chemicals disrupts the signaling pathways that CCDC128 could be part of, potentially hindering the protein's function. Rapamycin's inhibition of the mTOR pathway may also suppress essential pathways for the functional activity of CCDC128. Brefeldin A disturbs protein transport by inhibiting Arf, a key player in vesicle formation, thus potentially inhibiting CCDC128's role in trafficking processes. Similarly, Go6983 and GF109203X, which are inhibitors of protein kinase C (PKC) isoforms, can prevent necessary phosphorylation events of CCDC128. Finally, Genistein, by inhibiting tyrosine kinases, may disrupt additional signaling pathways or protein interactions necessary for CCDC128's function. Each of these chemicals, through their distinct mechanisms, can intersect with the pathways utilized by CCDC128, leading to its functional inhibition.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Since CCDC128 is involved in cellular processes that are regulated by PI3K signaling, such as membrane trafficking, wortmannin can inhibit CCDC128 by disrupting the PI3K pathway, which could lead to a functional inhibition of the protein's role in these processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 functions as another inhibitor of PI3K, similar to wortmannin. By inhibiting PI3K, LY294002 can disrupt downstream signaling that may be crucial for CCDC128's function in the cell, thereby indirectly inhibiting the function of CCDC128 by halting the necessary signaling events it requires. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor, and while it inhibits many kinases, its action can lead to the functional disruption of signaling pathways that involve CCDC128. The inhibition of a kinase that directly phosphorylates CCDC128 can result in the loss of CCDC128's activity, assuming phosphorylation is necessary for its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK). Given that CCDC128 is implicated in signal transduction, MEK inhibition by U0126 could disrupt signaling pathways that are required for the functional activity of CCDC128. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which is involved in stress responses and may be related to CCDC128 function. By targeting p38 MAP kinase, SB203580 can indirectly inhibit CCDC128 function by disrupting the signaling pathways that CCDC128 is a part of, assuming CCDC128 is involved in stress response signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which like U0126, acts upstream of ERK. By inhibiting MEK, PD98059 could lead to a decrease in ERK activation, potentially inhibiting the function of CCDC128 if CCDC128 is involved in ERK-mediated signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), which is implicated in a range of cellular processes. If CCDC128 participates in pathways regulated by JNK, inhibition by SP600125 could lead to functional inhibition of CCDC128 by disrupting the JNK signaling pathways that are necessary for CCDC128's activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mechanistic target of rapamycin (mTOR), a central regulator of cell growth and metabolism, which could be linked to CCDC128's function. Inhibition of mTOR by rapamycin could suppress pathways that are essential for the functional activity of CCDC128. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting ADP-ribosylation factor (Arf), a small GTPase involved in the formation of transport vesicles. Since CCDC128 is associated with cellular trafficking processes, inhibition of Arf by Brefeldin A can result in the functional inhibition of CCDC128's role in these processes. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 is a pan-PKC inhibitor that can inhibit protein kinase C (PKC) isoforms. Assuming CCDC128's function is regulated by PKC-mediated phosphorylation, Go6983 could inhibit the function of CCDC128 by preventing its necessary phosphorylation events. | ||||||