CBS Activators
Common CBS Activators include, but are not limited to Pyridoxine Hydrochloride CAS 58-56-0, L-Homocysteine CAS 6027-13-0, β-Estradiol CAS 50-28-2, D(+)Glucose, Anhydrous CAS 50-99-7 and Insulin CAS 11061-68-0.
Cystathionine beta-synthase (CBS) is a pivotal enzyme playing a central role in the metabolism of sulfur amino acids. Located within the intricate pathways of methionine and cysteine metabolism, CBS functions to catalyze the condensation of serine and homocysteine, producing cystathionine. This step is a cornerstone in the transsulfuration pathway, a process that facilitates the conversion of homocysteine to cysteine. CBS, with its pyridoxal 5'-phosphate (PLP) cofactor, is intricately involved in regulating homocysteine levels within the body, and its activity has implications for a multitude of biochemical pathways, including the synthesis of glutathione, a crucial antioxidant. The precise modulation and functionality of CBS are thus essential for maintaining a harmonious balance within sulfur amino acid metabolism, ensuring cellular health and systemic homeostasis.
Activators of CBS are molecules or compounds designed to enhance the activity or expression of the CBS enzyme. These activators may operate by promoting the transcription or translation of the CBS gene, stabilizing the enzyme's conformation, enhancing its cofactor binding, or increasing its catalytic efficiency towards substrates. The presence of CBS activators can significantly influence the dynamics of the transsulfuration pathway, optimizing the balance of sulfur amino acids and their downstream metabolites. Exploring the realm of CBS activators offers profound insights into the nuanced world of metabolic regulation and the molecular orchestrations that underpin amino acid biochemistry. As research continues to unravel the vast intricacies of cellular metabolism, the role of CBS and its activators stands as a compelling narrative, highlighting the delicate interplay of enzymes and metabolites that sustain life's biochemical rhythms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-(5'-Adenosyl)-L-methionine-d3 disulfate salt is an endogenous activator of CBS, enhancing its enzymatic activity and potentially its expression. | ||||||
Pyridoxine Hydrochloride | 58-56-0 | sc-219674 | 10 mg | $42.00 | ||
Pyridoxine Hydrochloride is a cofactor for CBS. Its presence is required for optimal enzymatic activity, potentially influencing CBS expression. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated levels of homocysteine might upregulate CBS expression as a compensatory mechanism to metabolize excess homocysteine. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can upregulate CBS expression, reducing homocysteine levels, especially evident during pregnancy. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
High glucose levels may downregulate CBS expression, contributing to elevated homocysteine in diabetic conditions. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin may modulate CBS expression, potentially influencing homocysteine metabolism. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
As a critical component of the one-carbon metabolism pathway, folic acid might influence CBS expression indirectly. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Elevated methionine levels can increase CBS expression as a way to handle excess methionine by converting it to cystathionine. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $51.00 $112.00 $449.00 $1151.00 $2178.00 | 1 | |
Cysteine can downregulate CBS expression, providing feedback inhibition. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine is involved in homocysteine remethylation. Its presence might influence CBS expression indirectly by affecting homocysteine levels. | ||||||