CBS Inhibitors

Common CBS Inhibitors include, but are not limited to Rimonabant Hydrochloride CAS 158681-13-1, AM-630 CAS 164178-33-0, SR 144528 CAS 192703-06-3, (±)-SLV 319 CAS 362519-49-1 and JTE 907 CAS 282089-49-0.

CBS inhibitors belong to a specific chemical class of compounds that have been meticulously designed to modulate the activity of cystathionine beta-synthase (CBS), an enzyme crucially involved in sulfur amino acid metabolism. CBS plays a significant role in catalyzing the condensation of homocysteine and serine to produce cystathionine, a pivotal step in the transsulfuration pathway that ultimately leads to the production of cysteine. These inhibitors are thoughtfully crafted molecules engineered to interact with CBS, influencing its normal function. Through these interactions, they might impact various cellular processes associated with sulfur amino acid metabolism, without directly altering its catalytic sites or its involvement in the biosynthesis of cysteine.

The design of CBS inhibitors is grounded in a comprehensive understanding of the structural and functional attributes of the enzyme. Typically developed using advanced chemical synthesis methods and informed by insights from enzymology and metabolic pathways, these inhibitors are characterized by their ability to selectively bind to CBS. This selectivity enables focused modulation of cellular pathways that rely on the activity of this specific enzyme. The development and utilization of CBS inhibitors contribute to advancing our understanding of the complex interplay between metabolic processes and cellular responses, offering insights into the fundamental molecular mechanisms that govern sulfur amino acid metabolism, redox balance, and the synthesis of essential biomolecules in various organisms.