caspase-14 Activators

Caspase-14, a member of the caspase family of proteases, is predominantly involved in skin differentiation and barrier formation. Unlike other caspases, it does not play a direct role in apoptosis but is crucial for the cornification process in the epidermis. The chemicals listed as activators of caspase-14 are diverse, including both naturally occurring compounds and synthetic molecules. Firstly, natural compounds like Resveratrol, Sulforaphane, Quercetin, and Curcumin, predominantly found in various plants, fruits, and spices, are known for their antioxidant properties. These compounds influence caspase-14 either by upregulating its expression or enhancing its activity. Resveratrol, found in grapes and berries, is particularly interesting due to its ability to modulate several cell signaling pathways, indirectly influencing caspase-14 activity. Sulforaphane, from cruciferous vegetables, and Quercetin, found in many fruits and vegetables, similarly affect caspase-14 by modulating cellular pathways that lead to its increased expression and activity. Synthetic compounds and external factors such as UVA light exposure also play a role in activating caspase-14. UVA light, through photochemical reactions in skin cells, can indirectly lead to the activation of caspase-14, essential for skin barrier formation and homeostasis. Retinoic Acid, a derivative of Vitamin A, is crucial in dermatology for its role in skin health, influencing caspase-14 among other cellular targets.