CapG Activators
CapG activators refer to a specialized group of chemical entities designed to enhance the activity of CapG, a gelsolin/villin family of actin-binding proteins that is implicated in the remodeling of the actin cytoskeleton. CapG functions to bind and sever actin filaments, thereby playing a pivotal role in cell motility, shape, division, and signaling. The regulation of actin dynamics by CapG is essential for various cellular processes, including the maintenance of cellular structure, intracellular transport, and the establishment of cell polarity.
Activators of CapG can exert their effects through direct interactions or via indirect pathways. Direct CapG activators bind to the protein and induce conformational changes that increase its affinity for actin, or they might act by stabilizing the active form of CapG, promoting its actin-severing and capping activities. These chemical agents can enhance the intrinsic ability of CapG to modulate actin dynamics by facilitating the formation of free barbed ends, which are critical for the polymerization of actin and subsequent cellular movements. Indirect activators may influence CapG activity through the modulation of signaling pathways that control CapG expression, localization, or post-translational modifications. This could involve the adjustment of cellular kinase or phosphatase activity, which can lead to the phosphorylation or dephosphorylation of CapG, thus altering its function. Alternatively, the regulation of other proteins that interact with CapG, or the modulation of calcium levels within the cell, could also indirectly affect CapG's actin-remodeling capabilities.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC is known to phosphorylate CapG, which enhances its function in actin filament sequestration and cell motility. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin is a calcium-binding messenger protein. It can bind to CapG in a calcium-dependent manner, enhancing CapG's actin sequestering activity. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
BIS-1 is a specific inhibitor of the IP3 receptor. Inhibition of the IP3 receptor leads to increased calcium levels, which can bind to CapG and enhance its function. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP can bind directly to CapG and modulate its actin binding and bundling activities, thereby enhancing its function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can increase cAMP levels, which in turn activates PKA. PKA downstream signaling can cause phosphorylation of CapG, enhancing its actin binding activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine can increase cAMP levels via adrenergic receptors activation, which can indirectly lead to the activation of PKA. PKA downstream signaling can lead to CapG phosphorylation and functional enhancement. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin can increase intracellular calcium levels by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase. Increased calcium levels can enhance CapG activity by promoting its interaction with actin filaments. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain inhibits the Na+/K+ ATPase, leading to increased intracellular sodium and calcium levels. This can enhance CapG's actin bundling activity by promoting its interaction with calcium. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate SIRT1, which is involved in the regulation of actin dynamics. Activation of this pathway can enhance the function of CapG. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the Nrf2 pathway, which regulates actin cytoskeleton remodeling. This can indirectly enhance the function of CapG. | ||||||