CapG Inhibitors
CapG inhibitors belong to a distinctive chemical class primarily designed to target the cellular protein known as CapG, short for capping protein Gelsolin-like. CapG itself is a multifunctional actin-binding protein that plays a crucial role in modulating actin dynamics within the cytoskeleton. Actin, a fundamental component of the cytoskeleton, is involved in various cellular processes such as cell motility, shape maintenance, and intracellular transport. CapG, through its ability to regulate actin filament capping and depolymerization, exerts control over these essential cellular functions.
The inhibitors designed for CapG specifically aim to modulate its activity, thereby influencing actin dynamics within the cell.CapG inhibitors are meticulously crafted to interact with the binding sites on the CapG protein, disrupting its normal function. This interference can result in altered actin filament capping and depolymerization dynamics, ultimately affecting cellular processes dependent on the proper regulation of the cytoskeleton. Researchers and drug developers are keenly interested in understanding the precise mechanisms of CapG inhibitors, as unraveling the intricacies of their interactions with CapG can provide valuable insights into the broader cellular signaling pathways and avenues for manipulating cellular behavior. The ongoing exploration of CapG inhibitors represents a promising area of research for those seeking to decipher the intricate dance of molecular players within the cellular landscape.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine is an alkaloid that can disrupt microtubule formation, a process that CapG is involved in. By disrupting this process, it may inhibit the function of CapG. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine is a plant-derived toxin known to bind tubulin, a protein that CapG interacts with. By binding to tubulin, colchicine can potentially interfere with the function of CapG. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can interfere with the normal function of CapG. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Similar to paclitaxel, docetaxel stabilizes microtubules and hence can inhibit the function of CapG. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. This can disrupt CapG function. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine is a derivative of estradiol and mechlorethamine. It can bind to microtubule-associated proteins (MAPs) and can potentially inhibit CapG function. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine is an alkaloid that can alter the dynamics of microtubule assembly, which can inhibit the function of CapG. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor known to inhibit kinesin Eg5, which can disrupt microtubule dynamics and hence inhibit CapG function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule dynamics by binding to tubulin, which can inhibit the function of CapG. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine is a potent microtubule-targeting agent that inhibits microtubule assembly, which can inhibit the function of CapG. | ||||||