CaMKIIβ Inhibitors
CaMKIIβ Inhibitors constitute a chemical class of compounds designed to selectively target and modulate the activity of CaMKIIβ, or Calcium/Calmodulin-Dependent Protein Kinase II beta. CaMKIIβ is a critical enzyme involved in intracellular calcium signaling and neuronal function, particularly in synaptic plasticity and memory processes. These inhibitors are typically small molecules or compounds engineered to interfere with the kinase activity of CaMKIIβ, disrupting its ability to phosphorylate target proteins in response to calcium signaling. This inhibition can impact various aspects of neuronal function, making CaMKIIβ Inhibitors valuable tools for researchers aiming to investigate the roles of CaMKIIβ in cellular processes.
The design and development of CaMKIIβ Inhibitors involve a deep understanding of the kinase's catalytic domains and regulatory mechanisms. These inhibitors often target specific regions of CaMKIIβ's structure that are critical for its enzymatic activity. By binding to and modulating these regions, CaMKIIβ Inhibitors can prevent the kinase from phosphorylating its substrates, thereby influencing downstream signaling pathways. Research into CaMKIIβ Inhibitors is instrumental for elucidating the roles of CaMKIIβ in cellular processes, especially in synaptic plasticity and learning and memory.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a specific inhibitor of CaMKII. By inhibiting the kinase activity, it could potentially lead to a downregulation of its expression through negative feedback mechanisms. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 is another potent and selective inhibitor of CaMKII. It can block the kinase's activity, potentially leading to decreased expression or activity of CaMKIIβ. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Trifluoperazine is an antipsychotic drug that can inhibit calmodulin, a protein that activates CaMKIIβ. By inhibiting calmodulin, it may indirectly down-regulate CaMKIIβ. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin antagonist. By blocking calmodulin, it can indirectly inhibit the activation and possibly the expression of CaMKIIβ. | ||||||
STO-609 | 52029-86-4 | sc-507444 | 5 mg | $140.00 | ||
STO-609 is a known inhibitor of CaMK kinase. Although it primarily targets CaMKK, it might have indirect effects on the expression or activity of downstream targets like CaMKIIβ. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker. By reducing intracellular calcium levels, it might indirectly inhibit the activation and potential expression of CaMKIIβ. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is another calcium channel blocker that might indirectly affect the activation and expression of CaMKIIβ by reducing intracellular calcium levels. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, can reduce calcium influx into cells. This may lead to decreased activation of CaMKIIβ and potentially its expression. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine, by inhibiting calcium influx, can potentially decrease the activation and subsequent expression of CaMKIIβ. | ||||||
Ramipril | 87333-19-5 | sc-205833 sc-205833A sc-205833B sc-205833C sc-205833D | 500 mg 1 g 2 g 5 g 10 g | $175.00 $240.00 $357.00 $719.00 $1229.00 | 1 | |
Ramipril is an ACE inhibitor that has been shown to reduce the expression of CaMKII in certain contexts, potentially including CaMKIIβ. | ||||||