Molecular structure of Ramipril, CAS Number: 87333-19-5
Ramipril (CAS 87333-19-5)
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Alternate Names:
(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-cyclopenta[b]pyrrole-2-carboxylic acid
Application:
Ramipril is an inhibitor of the angiotensin- coverting enzyme (ACE)
CAS Number:
87333-19-5
Purity:
≥98%
Molecular Weight:
416.51
Molecular Formula:
C23H32N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ramipril is an inhibitor of the ACE (angiotensin- converting enzyme) that is reported to quickly hydrolyze into the active metabolite Ramiprilat. The enzyme ACE plays a role in the renin-angiotensin system (RAS). Studies indicate that Ramipril is a more potent inhibitor in comparison to Zofenopril, which we supply in its calcium salt form (sc-208496). Ramipril increases IL-10, and decreases the levels of MCP-1 and IL-18. Further investigations might focus on understanding the kinetics and the biochemical pathways affected by ACE inhibition.
Ramipril (CAS 87333-19-5) References
- Spotlight on ramipril in the prevention of cardiovascular outcomes. | Warner, GT. and Perry, CM. 2003. Am J Cardiovasc Drugs. 3: 113-6. PMID: 14727938
- Stability of ramipril in the solvents of different pH. | Hanysová, L., et al. 2005. J Pharm Biomed Anal. 37: 1179-83. PMID: 15862704
- Effects of ramipril on serum monocyte chemoattractant protein 1, interleukin-18, and interleukin-10 in elderly patients with acute coronary syndrome. | Chen, HQ., et al. 2010. Heart Vessels. 25: 77-81. PMID: 20339966
- Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 382: 455-61. PMID: 20848272
- Not all angiotensin-converting enzyme inhibitors are equal: focus on ramipril and perindopril. | Dinicolantonio, JJ., et al. 2013. Postgrad Med. 125: 154-68. PMID: 23933903
- Paediatric drug development of ramipril: reformulation, in vitro and in vivo evaluation. | Russell, C., et al. 2015. J Drug Target. 23: 854-63. PMID: 25950602
- Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat after intravenous and oral doses of ramipril in healthy horses. | Serrano-Rodríguez, JM., et al. 2016. Vet J. 208: 38-43. PMID: 26639833
- Binding interaction of ramipril with bovine serum albumin (BSA): Insights from multi-spectroscopy and molecular docking methods. | Shi, JH., et al. 2016. J Photochem Photobiol B. 164: 103-111. PMID: 27664380
- Ramipril reduces incidence and prolongates latency time of radiation-induced rat myelopathy after photon and carbon ion irradiation. | Saager, M., et al. 2020. J Radiat Res. 61: 791-798. PMID: 32657322
- Degradation of ramipril by residues from the brewing industry: A new carbon-based photocatalyst compound. | Leichtweis, J., et al. 2021. Chemosphere. 281: 130987. PMID: 34289631
- Study of possible sex features of ramipril and candesartan treatment under experimental arterial hypertension in rats. | Tsubanova, N., et al. 2022. Ceska Slov Farm. 71: 116-120. PMID: 36058640
- Clinical pharmacokinetics of ramipril. | Meisel, S., et al. 1994. Clin Pharmacokinet. 26: 7-15. PMID: 8137599
- Stability of ramipril in water, apple juice, and applesauce. | Allen, LV., et al. 1995. Am J Health Syst Pharm. 52: 2433-6. PMID: 8564609
Inhibitor of:
ACE, Ace3, AGT1, AGTRAP, Angiotensin, Angiotensinase C, CaMKIIβ, Doc2g, Enzyme, Klkb16, Myotrophin, Olfr1018, Olr14, Olr1472, Olr1479, Olr1499, Olr1511, Olr400, Olr419, Olr420, Olr434, Olr806, V1RA6, and WNK3.Activator of:
ANG IV, bradykinin, and Renin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ramipril, 500 mg | sc-205833 | 500 mg | $179.00 | |||
Ramipril, 1 g | sc-205833A | 1 g | $245.00 | |||
Ramipril, 2 g | sc-205833B | 2 g | $364.00 | |||
Ramipril, 5 g | sc-205833C | 5 g | $733.00 | |||
Ramipril, 10 g | sc-205833D | 10 g | $1254.00 |