CaMKIIβ Activators
The CaMKIIβ activators are a collection of diverse chemicals that either directly or indirectly influence the activity of CaMKIIβ, a crucial kinase involved in various cellular processes. While most of the listed chemicals are inhibitors, it is essential to understand their inhibitory actions to appreciate how they modulate CaMKIIβ activity. NAP-TAS offers a unique photoactivatable inhibition, releasing an active inhibitor upon UV exposure. Dantrolene indirectly modulates CaMKIIβ by regulating intracellular Ca2+ levels through inhibition of Ca2+ release from the sarcoplasmic reticulum.
PD98059 is a MEK inhibitor that negatively regulates the MAPK/ERK pathway, influencing CaMKIIβ activity. Calyculin A inhibits protein phosphatases 1 and 2A, resulting in sustained CaMKIIβ activity, as these phosphatases typically dephosphorylate and inactivate CaMKII. FK506, by inhibiting calcineurin, indirectly maintains CaMKIIβ in a phosphorylated and active state, as calcineurin dephosphorylates and inactivates CaMKIIβ. W-7 serves as a calmodulin antagonist, indirectly affecting CaMKIIβ by preventing Ca2+/calmodulin binding.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-(4-Azido-2-nitrophenyl)-2-aminoethylsulfonate, Sodium Salt, Dihydrate | 352000-05-6 | sc-211975 | 10 mg | $320.00 | ||
NAP-TAS is a photoactivatable CaMKII inhibitor. Upon exposure to UV light, it releases a sulfonamide derivative that specifically inhibits CaMKII activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits Ca2+ release from the sarcoplasmic reticulum, indirectly affecting CaMKII by modulating intracellular Ca2+ levels. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that negatively regulates the MAPK/ERK pathway. Inhibition of this pathway can impact CaMKIIβ activity, as it is known to be modulated by MAPK/ERK signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a protein phosphatase 1 and 2A inhibitor. Inhibition of these phosphatases results in sustained CaMKIIβ activity, as they typically dephosphorylate and inactivate CaMKII. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 inhibits calcineurin, indirectly impacting CaMKII activity. Calcineurin dephosphorylates and inactivates CaMKII; thus, its inhibition by FK506 maintains CaMKII in a phosphorylated and active state. | ||||||