CaMK1G Activators
CaMK1G Activators encompass a diverse set of chemical compounds that indirectly promote the functional activity of CaMK1G through various cellular mechanisms. Forskolin, Isoproterenol, and Dibutyryl-cAMP (db-cAMP) function by enhancing adenylate cyclase activity to raise intracellular cAMP levels, leading to PKA activation. PKA, in turn, phosphorylates substrates that may include kinases in the CaMK1G signaling cascade, thereby indirectly facilitating CaMK1G activation. Similarly, 8-Bromo-cAMP, a cAMP analog, also activates PKA, contributing to the phosphorylation and subsequent activation of CaMK1G. Nicotinic acid and Bay K 8644, by increasing intracellular calcium, directly activate calmodulin, which then binds to and activates CaMK1G, altering its conformation for increased activity. The calcium ionophore A23187 exerts its effect by directly elevating calcium levelsinside cells, allowing calmodulin to activate CaMK1G, while Ouabain indirectly increases calcium levels via Na+/K+ ATPase inhibition, ultimately leading to CaMK1G activation.
The activation dynamics of CaMK1G are further modulated by compounds that influence the signaling environment within the cell. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which can engage in signaling cross-talk, resulting in the phosphorylation of proteins that could include components of the CaMK1G pathway, indirectly enhancing CaMK1G activity. Anisomycin activates the JNK pathway, potentially affecting the CaMK1G signaling network and indirectly promoting its activity. Conversely, H-89 and Bisindolylmaleimide I act as inhibitors of PKA and PKC, respectively, altering the balance of kinase activity within the cell, which may lead to compensatory mechanisms that indirectly upregulate CaMK1G activity. Through these intricate networks of kinase signaling, these diverse activators orchestrate a symphony of molecular events leading to the enhancement of CaMK1G, without directly interacting with the gene product of CAMK1G itself. These chemicals fine-tune the cellular machinery to promote an environment conducive to CaMK1G activation, leveraging indirect pathways to achieve their effects.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing the intracellular levels of cAMP. Elevated cAMP activates PKA, which can phosphorylate and thereby enhance the activity of CaMK1G, as PKA-mediated phosphorylation events often lead to the activation of downstream kinases. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid binds to G protein-coupled receptors, which can activate the phospholipase C pathway, resulting in increased intracellular calcium. Elevated calcium levels can activate calmodulin, which directly activates CaMK1G through binding and conformational change. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that can modulate downstream pathways that influence CaMK1G. PMA’s activation of PKC can lead to cross-talk between signaling pathways and subsequent phosphorylation events that enhance the activity of CaMK1G. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a PKA inhibitor that can lead to altered signaling dynamics within kinase networks, potentially resulting in compensatory mechanisms that indirectly enhance the activity of CaMK1G through feedback loops. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable analog of cAMP that activates PKA. This activation can lead to enhanced phosphorylation of downstream kinases including CaMK1G, thus indirectly augmenting its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
The calcium ionophore A23187 increases intracellular calcium concentration, which can activate calmodulin. The Ca2+-calmodulin complex then directly activates CaMK1G by binding to its regulatory domain and inducing a conformational change that increases its kinase activity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 is an L-type calcium channel agonist that increases calcium influx, thereby raising intracellular calcium levels. Elevated calcium can activate calmodulin, which in turn directly activates CaMK1G through its regulatory domain. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cAMP analog that activates PKA, leading to phosphorylation events within kinase cascades that can indirectly enhance the activity of CaMK1G. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator which can trigger the JNK signaling pathway. Activation of JNK may influence the activity of CaMK1G through upstream signaling events or kinase cascades that lead to its activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that disrupts PKC-mediated pathways, which could lead to a shift in cellular signaling dynamics that indirectly result in the enhancement of CaMK1G activity. | ||||||