CaM IV Inhibitors
CaM IV inhibitors are chemical compounds that directly or indirectly impact the function of CaM IV, a protein involved in several signaling pathways. Compounds like KN-93, W-7, Trifluoperazine, Staurosporine, CGP 53353, H-89, KT 5720, Chelerythrine, Gö 6983, U0126, and PD 98059 can lead to decreased functional activity of CaM IV through specific signaling pathways or biological processes that it is directly involved in.
For instance, KN-93 and CGP 53353 are selective inhibitors of Ca2+/calmodulin-dependent protein kinase II (CaMKII), an upstream regulator of CaM IV. These compounds inhibit CaMKII, which in turn results in decreased activity of CaM IV. W-7 and Trifluoperazine are calmodulin antagonists which inhibit the binding of Ca2+/calmodulin to its target proteins, thereby indirectly decreasing CaM IV activity. A-kinase anchor protein disruptor inhibits the interaction between AKAP and PKA, another upstream regulator of CaM IV, which can result in decreased activity of CaM IV.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII by KN-93 can decrease CaM IV activity because CaMKII is an upstream regulator of CaM IV in many signaling cascades. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin antagonist. It inhibits the binding of Ca2+/calmodulin to its target proteins, which will indirectly decrease the activity of CaM IV as it is one of the target proteins of calmodulin. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Trifluoperazine is a calmodulin antagonist. It inhibits the binding of Ca2+/calmodulin to its target proteins, thereby indirectly decreasing CaM IV activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. By inhibiting protein kinases which phosphorylate CaM IV, it can lead to decreased activity of CaM IV. | ||||||
DAPH-7 | 145915-60-2 | sc-200699 | 1 mg | $71.00 | 1 | |
DAPH-7 is a selective inhibitor of CaMKII. By inhibiting CaMKII, an upstream regulator of CaM IV, it can lead to decreased activity of CaM IV. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a potent inhibitor of protein kinase A. Because PKA phosphorylates and regulates CaM IV, inhibition of PKA by H-89 can result in decreased CaM IV activity. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT 5720 is a potent inhibitor of protein kinase A (PKA). By inhibiting PKA, which phosphorylates and regulates CaM IV, KT 5720 can decrease the activity of CaM IV. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent, selective inhibitor of protein kinase C (PKC). As PKC can phosphorylate and regulate CaM IV, inhibition of PKC by Chelerythrine can lead to decreased CaM IV activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad spectrum PKC inhibitor. By inhibiting PKC, which can phosphorylate and regulate CaM IV, it can lead to decreased CaM IV activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of MEK1. By inhibiting MEK1, which can phosphorylate and regulate CaM IV, PD 98059 can lead to decreased CaM IV activity. | ||||||