DAPH-7 (CAS 145915-60-2)
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DAPH-7 is a highly selective procarcinogenic protein kinase C-betaII (PKCbetaII) inhibitor that can also inhibit nPKCs and aPKCs, and upregulate VCAM-1, in a dose dependent manner. The compound may act to inhibit a variety of kinases, such as, protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 muM. Studies show that inhibitory DAPHs can reconstruct Sup35 prion-specific intermolecular interfaces to create morphologically altered aggregates with diminished infectivity and self-templating activity. When DAPHs alter the folding of Sup35s amyloidogenic core it blocks amyloidogenic oligomerization and specific recognition events that nucleate prion assembly. Research shows that DAPH-7, also known as, CGP-53353, can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells.
DAPH-7 (CAS 145915-60-2) References
- Social and psychological risk factors in coronary heart disease. | Syme, SL. 1975. Mod Concepts Cardiovasc Dis. 44: 17-21. PMID: 1094270
- Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. | Kouroedov, A., et al. 2004. Circulation. 110: 91-6. PMID: 15210597
- Aggregator compounds confound amyloid fibrillization assay. | Rishton, GM. 2008. Nat Chem Biol. 4: 159-60. PMID: 18277973
- Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. | Wang, H., et al. 2008. Proc Natl Acad Sci U S A. 105: 7159-64. PMID: 18480256
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAPH-7, 1 mg | sc-200699 | 1 mg | $71.00 |