Date published: 2025-11-5

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Calpain 10 Activators

Calpain 10 activators refer to a diverse group of chemicals that are capable of modulating the activity of the calpain 10 enzyme, a member of the calpain family of calcium-dependent, non-lysosomal cysteine proteases. The function of calpain 10, like other calpains, is involved in various cellular processes including signal transduction, cytoskeletal remodeling, and cell cycle progression. However, calpain 10 has unique tissue distribution and substrate specificity, which suggests that it may play specialized roles in cellular metabolism and regulation. These activators may promote the enzymatic function of calpain 10 either by a direct interaction with the protease or through indirect mechanisms that facilitate its activation. Direct activators of calpain 10 likely bind to specific regions of the protein, such as the catalytic domain or the calcium-binding sites, potentially inducing conformational changes that increase the enzyme's affinity for calcium or its substrates. This interaction may mimic the natural activation process of calpains, which involves calcium binding and subsequent conformational changes leading to the exposure of the active site and the cleavage of target substrates. Indirect activators might enhance calpain 10 activity by increasing intracellular calcium concentration, which is essential for the activation of all calpains, or by modulating the expression and stability of calpain 10 at the transcriptional or post-translational level. For example, signaling molecules that raise intracellular calcium levels could serve as indirect activators, as could molecules that modify calpain 10 post-translationally to prevent its degradation or promote its proper localization within the cell.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Calcium chloride anhydrous

10043-52-4sc-207392
sc-207392A
100 g
500 g
$65.00
$262.00
1
(1)

Calcium Chloride can increase intracellular calcium levels, which directly activates Calpain 10. Calpain 10 is a calcium-activated neutral protease and its activation is dependent on calcium ions.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA is a diester of phorbol and a potent tumor promoter often used in biomedical research to activate the signal transduction enzyme, protein kinase C. Activation of PKC can lead to an increase in intracellular calcium levels, which would then activate Calpain 10.

(±)-Bay K 8644

71145-03-4sc-203324
sc-203324A
sc-203324B
1 mg
5 mg
50 mg
$82.00
$192.00
$801.00
(0)

Bay K8644 is a calcium channel agonist that increases intracellular calcium levels, leading to the activation of Calpain 10.

Ryanodine

15662-33-6sc-201523
sc-201523A
1 mg
5 mg
$219.00
$765.00
19
(2)

Ryanodine is a plant alkaloid that modifies the ryanodine receptor and causes the release of calcium from the endoplasmic reticulum, thereby increasing intracellular calcium concentrations and activating Calpain 10.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin is a sesquiterpene lactone that inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in intracellular calcium levels and thereby activating Calpain 10.

Ionomycin, free acid

56092-81-0sc-263405
sc-263405A
1 mg
5 mg
$94.00
$259.00
2
(2)

Ionomycin is a calcium ionophore that increases intracellular calcium levels, which is essential for the activation of Calpain 10.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 is a calcium ionophore that increases intracellular calcium concentrations, leading to the activation of Calpain 10.

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$58.00
$170.00
15
(1)

Nifedipine is a calcium channel blocker that can indirectly increase intracellular calcium levels by inducing a compensatory response in the cell, thereby activating Calpain 10.

Verapamil

52-53-9sc-507373
1 g
$367.00
(0)

Verapamil is a calcium channel blocker that, similar to Nifedipine, can indirectly increase intracellular calcium levels by inducing a compensatory response in the cell, leading to the activation of Calpain 10.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$27.00
$52.00
37
(1)

2-APB acts as an IP3 receptor antagonist that can indirectly increase intracellular calcium levels by inducing a compensatory response in the cell, leading to the activation of Calpain 10.