calmin Activators
Calmin activators is centered on the premise that modulation of cellular signaling and trafficking pathways can indirectly impact the function of CLMN, a protein implicated in intracellular trafficking processes. Given the current understanding of CLMN's involvement in cellular trafficking, compounds that influence these pathways can serve as indirect activators. For instance, forskolin and cholera toxin both raise intracellular cAMP levels, which could impact CLMN by altering protein kinase A (PKA) activity and downstream targets involved in vesicular transport. Phorbol esters like PMA activate protein kinase C, another key regulator of trafficking, and by modulating these pathways, can influence CLMN's function.
Ion homeostasis and signal transduction are other aspects that can affect CLMN activity. Compounds such as manganese (II) chloride, ionomycin, and monensin alter intracellular ion concentrations, thereby impacting signal transduction and vesicular trafficking. Genistein and NAD+ modulate various signal transduction pathways and enzyme activities, which can lead to changes in the trafficking machinery involving CLMN. Moreover, agents like epigallocatechin gallate and brefeldin A affect the endocytic and secretory pathways, respectively, potentially modulating CLMN activity. Lastly, 5-azacytidine, through its effects on gene expression, might indirectly influence the expression of CLMN or associated proteins, thereby affecting its functional state within the cell.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, raising cAMP levels, which can lead to activation of PKA. PKA can phosphorylate substrates involved in vesicular trafficking, potentially affecting CLMN activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Affects endocytic pathway dynamics, which could modulate intracellular trafficking processes involving CLMN. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Functions as a cofactor for many enzymes, some of which are involved in vesicular trafficking, a process where CLMN may play a role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, which is involved in the regulation of intracellular transport that can influence CLMN function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor that by modifying signaling pathways, may indirectly influence intracellular trafficking and hence CLMN function. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a substrate for sirtuins, it can modulate intracellular signaling pathways, potentially influencing CLMN activity through deacetylation processes. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Acts as a second messenger that can modulate a variety of signaling pathways, potentially affecting CLMN by altering the dynamics of vesicular trafficking. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can alter gene expression patterns, possibly affecting the expression of proteins involved in CLMN-mediated processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi apparatus function and could modulate the vesicular trafficking pathways where CLMN is involved. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that alters intracellular ion gradients, influencing vesicle formation and trafficking potentially related to CLMN function. | ||||||