Calcipressin-3 Inhibitors
Calcipressin-3 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of Calcipressin-3, a member of the Calcipressin family of proteins that function as endogenous regulators of calcineurin, a calcium and calmodulin-dependent serine/threonine phosphatase. Calcipressin-3 binds to calcineurin and acts as an inhibitory protein, modulating its phosphatase activity. Calcineurin is involved in various cellular processes, primarily by dephosphorylating nuclear factor of activated T-cells (NFAT) proteins, allowing them to enter the nucleus and regulate gene transcription. Calcipressin-3 prevents this dephosphorylation, thus controlling the downstream effects of calcium signaling within the cell. Inhibitors of Calcipressin-3 interfere with its ability to bind and regulate calcineurin, thereby allowing calcineurin to remain active and influence cellular processes that depend on calcium signaling.
By inhibiting Calcipressin-3, researchers can explore the intricate balance of calcium signaling and how its dysregulation affects cellular physiology. Calcipressin-3 plays a critical role in controlling the intensity and duration of calcineurin signaling, which is fundamental to processes such as gene expression, cell growth, and differentiation. Inhibiting Calcipressin-3 activity allows scientists to investigate how prolonged or enhanced calcineurin activity impacts cellular function and how Calcipressin-3 contributes to the fine-tuning of this signaling pathway. Studying Calcipressin-3 inhibitors helps elucidate the role of this protein in maintaining calcium homeostasis and its broader influence on cellular responses to environmental cues, highlighting the complexity of calcineurin regulation in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A may suppress Calcipressin-3 expression by directly inhibiting the calcineurin enzyme, thereby preventing the dephosphorylation and activation of NFAT transcription factors. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK-506 could reduce the transcription of Calcipressin-3 by binding to FKBP12 and forming a complex that inhibits calcineurin, leading to decreased NFAT activity in the nucleus. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may lead to the downregulation of Calcipressin-3 by inhibiting mTOR, a kinase that plays a crucial role in cell growth and protein synthesis, which could have downstream effects on gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent may decrease Calcipressin-3 expression by causing the demethylation of CpG islands within the gene promoter, resulting in a more transcriptionally inactive chromatin state. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to reduced Calcipressin-3 levels by selectively incorporating into DNA and disrupting the methylation pattern, which may silence gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A might downregulate Calcipressin-3 by inhibiting histone deacetylases, leading to an open chromatin configuration and suppression of gene transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could decrease Calcipressin-3 expression by inhibiting histone deacetylases, which would enhance the acetylation of histones and lead to transcriptional repression of specific genes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might reduce Calcipressin-3 expression by binding to its nuclear receptors and altering the transcriptional activity of genes without directly affecting the gene's promoter methylation status. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride could inhibit Calcipressin-3 by disrupting glycogen synthase kinase-3 beta (GSK-3β) activity, which is implicated in several transcriptional regulation pathways. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid sodium salt may downregulate Calcipressin-3 by inhibiting histone deacetylase, causing an increase in histone acetylation and a subsequent decrease in gene expression. | ||||||