CAGE-1 Inhibitors
Chemical inhibitors of CAGE-1 function primarily by disrupting various signaling pathways that CAGE-1 is part of or interacts with. Rapamycin directly targets mTOR, a crucial kinase in the mTOR signaling pathway to which CAGE-1 is associated, leading to attenuation of CAGE-1-related growth signals. Similarly, PP242 and Torin 1, by inhibiting both mTORC1 and mTORC2 complexes, downregulate the mTOR pathway activity, thus reducing CAGE-1 function. Ku-0063794 also targets these mTOR complexes, further contributing to the decrease in mTOR signaling and consequently CAGE-1 activity. PF-4708671 specializes in the inhibition of S6K1, which operates downstream of mTOR; this results in a reduction of CAGE-1-mediated signaling essential for protein synthesis and cell proliferation.
Furthermore, LY294002 and Wortmannin are inhibitors that target PI3K in the PI3K/Akt/mTOR pathway. By inhibiting PI3K, these compounds decrease Akt phosphorylation and subsequent mTOR activity, which indirectly suppresses CAGE-1 function. Triciribine specifically inhibits Akt, and by doing so, it also reduces the downstream signaling that enhances CAGE-1 function. Additionally, U0126 and PD98059 are selective inhibitors of MEK1/2 and MEK respectively, which are upstream of ERK in the MAPK/ERK pathway. Since this pathway can intersect with those involving CAGE-1, the inhibition of MEK by these compounds leads to reduced CAGE-1 signaling. Lastly, SB203580 and SP600125 inhibit p38 MAP kinase and JNK, both of which are part of the MAPK pathway. As MAPK activity can influence CAGE-1, the inhibition of these kinases by SB203580 and SP600125 results in a decrease in CAGE-1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, a kinase involved in the mTOR signaling pathway, which CAGE-1 is known to be a part of, leading to inhibition of CAGE-1 associated growth and proliferation signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which is upstream in the PI3K/Akt/mTOR pathway, a pathway in which CAGE-1 operates; inhibition of PI3K decreases Akt phosphorylation and mTOR activity, thereby inhibiting CAGE-1 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Acts as an inhibitor of PI3K in the PI3K/Akt/mTOR pathway, which is central to CAGE-1 function; through PI3K inhibition, it indirectly inhibits the function of CAGE-1 by reducing the pathway's activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Specifically inhibits Akt, which is part of the PI3K/Akt/mTOR pathway that influences CAGE-1; by inhibiting Akt, it reduces the downstream signaling that would otherwise enhance CAGE-1 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Selectively inhibits MEK1/2, which are upstream of ERK in the MAPK/ERK pathway, a pathway that can intersect with pathways involving CAGE-1, leading to functional inhibition of CAGE-1 through reduced signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which works upstream of ERK in the MAPK/ERK pathway; as this pathway can be linked to CAGE-1 function, PD98059 can inhibit CAGE-1 by reducing the pathway's signaling cascade. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase, which is part of the MAPK pathway; given that CAGE-1 is involved in pathways that are modulated by MAPK, inhibition of p38 can lead to decreased CAGE-1 signaling and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which is part of the MAPK pathway; because CAGE-1 operates within signaling pathways that can be influenced by MAPK activity, inhibition of JNK can decrease CAGE-1 function. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $175.00 $700.00 | 9 | |
S6K1 inhibitor, which acts downstream of mTOR; since CAGE-1 is involved in the mTOR pathway, inhibiting S6K1 can lead to a decrease in CAGE-1-mediated signaling involved in protein synthesis and cell growth. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
Inhibits both mTORC1 and mTORC2 complexes, and since CAGE-1 is linked to the mTOR pathway, inhibition by PP242 would reduce CAGE-1 activity related to cell growth and metabolism. | ||||||