cadherin-22 Activators
Cadherin-22 Activators are a diverse group of compounds that enhance the functional activity of cadherin-22 through various biochemical and cellular pathways. Forskolin, through its elevation of cAMP, activates PKA, which can lead to the phosphorylation of cadherin-22 or associated proteins, promoting the integrity and function of cadherin-22 in cell adhesion. Epidermal Growth Factor, by activating EGFR, initiates downstream signaling that bolsters the cytoskeletal arrangements necessary for cadherin-22 to effectively mediate cell adhesion. Compounds like PMA and Calyculin A specifically target protein kinases and phosphatases, respectively, modifying the phosphorylation status of proteins that interact with or are part of the cadherin-catenin complex, leading to enhanced cadherin-22-mediated adhesion.
MnCl2 and N-Acetylglucosamine influence the functional activity of cadherin-22 through integrin activation and glycosylation modification, respectively. These modifications are crucial for the proper function of cadherin-22 in cell-cell adhesion. ROCK inhibitors like Thiazovivin and Y-27632 reduce cytoskeletal tension, thereby favoring the formation of cell-cell adhesions mediated by cadherin-22. SB-431542 and DAPT modulate signaling pathways such as TGF-beta and Notch, which can lead to an increase in the expression and functional activity of cadherin-22. Lastly, GSK-3 inhibitors like Lithium Chloride and BIO stabilize the interaction between beta-catenin and cadherin-22, reinforcing the cell adhesion function of cadherin-22.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit GSK-3beta, leading to the stabilization of beta-catenin, a molecule that interacts with cadherins to modulate cell adhesion. Enhanced beta-catenin levels can promote the functional activity of cadherin-22 by reinforcing cell-cell adhesion complexes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, raising intracellular cAMP levels, which can lead to the activation of PKA. PKA phosphorylation can influence the arrangement of cytoskeletal elements and enhance the functional activity of cadherin-22 by promoting its association with the cytoskeleton. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC, which can phosphorylate proteins associated with the cadherin-catenin complex, potentially enhancing the stability and adhesive function of cadherin-22. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a serine/threonine phosphatase inhibitor that can lead to increased phosphorylation levels of proteins within cadherin-catenin complexes, enhancing the functional activity of cadherin-22 by promoting stronger cell-cell adhesion. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese chloride is known to activate integrins, which can synergize with cadherins to strengthen cell adhesion. Enhanced integrin signaling can indirectly enhance the functional activity of cadherin-22 by promoting adhesion complex stability. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $92.00 $159.00 $300.00 | 1 | |
N-Acetylglucosamine can modify the glycosylation status of cell adhesion molecules, potentially enhancing the functional activity of cadherin-22 by improving its stability and adhesion properties. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $278.00 $622.00 | 15 | |
Thiazovivin is a Rho-associated protein kinase (ROCK) inhibitor, which can enhance the functional activity of cadherin-22 by reducing actomyosin contractility, thereby favoring cell-cell adhesion over cell-matrix adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 also inhibits ROCK, enhancing the functional activity of cadherin-22 by a similar mechanism to Thiazovivin, promoting cell-cell adhesion dynamics. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 is an inhibitor of the TGF-beta receptor, which can lead to altered cellular differentiation states and enhance the functional activity of cadherin-22 in cell types where its expression is promoted. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a gamma-secretase inhibitor which can prevent the cleavage and activation of Notch signaling. Notch can regulate the expression of various cadherins, and inhibition of Notch can enhance the functional activity of cadherin-22 by altering cell fate decisions that lead to increased cadherin-22 expression. | ||||||