cadherin-22 Activators

Cadherin-22 Activators are a diverse group of compounds that enhance the functional activity of cadherin-22 through various biochemical and cellular pathways. Forskolin, through its elevation of cAMP, activates PKA, which can lead to the phosphorylation of cadherin-22 or associated proteins, promoting the integrity and function of cadherin-22 in cell adhesion. Epidermal Growth Factor, by activating EGFR, initiates downstream signaling that bolsters the cytoskeletal arrangements necessary for cadherin-22 to effectively mediate cell adhesion. Compounds like PMA and Calyculin A specifically target protein kinases and phosphatases, respectively, modifying the phosphorylation status of proteins that interact with or are part of the cadherin-catenin complex, leading to enhanced cadherin-22-mediated adhesion.

MnCl2 and N-Acetylglucosamine influence the functional activity of cadherin-22 through integrin activation and glycosylation modification, respectively. These modifications are crucial for the proper function of cadherin-22 in cell-cell adhesion. ROCK inhibitors like Thiazovivin and Y-27632 reduce cytoskeletal tension, thereby favoring the formation of cell-cell adhesions mediated by cadherin-22. SB-431542 and DAPT modulate signaling pathways such as TGF-beta and Notch, which can lead to an increase in the expression and functional activity of cadherin-22. Lastly, GSK-3 inhibitors like Lithium Chloride and BIO stabilize the interaction between beta-catenin and cadherin-22, reinforcing the cell adhesion function of cadherin-22.