cadherin-20 Inhibitors
Cadherin-20 inhibitors are chemicals that can indirectly modulate the function or expression of Cadherin-20, a calcium-dependent cell adhesion molecule. Central to the action of many of these inhibitors is their ability to perturb cellular calcium levels or signaling. For instance, EGTA, a calcium chelator, can disrupt the calcium-dependent binding of cadherins, which is integral to their adhesive function. Similarly, 2-APB, which modulates intracellular calcium dynamics, can interfere with the calcium-dependent operation of Cadherin-20.
Another significant aspect of cadherin function is their integration with the actin cytoskeleton, which ensures effective cell-cell adhesion. In this context, compounds like Blebbistatin, Cytochalasin D, ML-7, and Y-27632 emerge as important modulators. These chemicals target various components of the cytoskeleton and its associated kinases, impacting the dynamics of the actin network. This can lead to alterations in how Cadherin-20, and other cadherins, anchor to the cytoskeleton, thereby affecting their adhesive capabilities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Calcium chelator that can disrupt calcium-dependent cadherin binding, potentially influencing Cadherin-20 adhesion. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Modulates intracellular calcium levels which can affect calcium-dependent cadherin function, potentially impacting Cadherin-20. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Myosin II inhibitor that can affect actin cytoskeleton dynamics, indirectly impacting cadherin-mediated cell-cell adhesion including Cadherin-20. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization, potentially impacting the anchoring of cadherins like Cadherin-20 to the cytoskeleton. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase, affecting cytoskeleton dynamics and possibly Cadherin-20-mediated adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Rho-associated protein kinase (ROCK) inhibitor which can affect actin dynamics and thus influence Cadherin-20 functions. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
Another ROCK inhibitor impacting cytoskeletal dynamics, potentially affecting Cadherin-20 adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that can alter cell adhesion dynamics, potentially modulating Cadherin-20 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that can affect cell-cell adhesion pathways, possibly impacting Cadherin-20. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src kinase inhibitor which can modulate cadherin-associated signaling and potentially influence Cadherin-20 functions. | ||||||