C9orf114 Activators
C9orf114 activators include a variety of chemical compounds that indirectly enhance the functional activity of C9orf114 by modulating distinct intracellular signaling pathways. Forskolin, for instance, by raising intracellular cAMP levels, indirectly promotes C9orf114's activity by activating protein kinase A (PKA), which subsequently phosphorylates proteins that may interact with and enhance the activity of C9orf114. The cAMP analog 8-Br-cAMP also activates PKA, leading to a similar enhancement of C9orf114 function via phosphorylation of associated proteins. Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium levels, which can activate calcium-dependent kinases that modulate the activity of C9orf114, highlighting the importance of calcium signaling in the regulation of C9orf114's activity.
Further, compounds like Epigallocatechin gallate (EGCG) and Genistein operate through kinase inhibition, with EGCG potentially enhancing C9orf114 activity by inhibiting alternative pathways that compete with C9orf114's signaling, allowing for more predominant C9orf114-related activity. LY294002 and U0126, inhibitors of PI3K and MEK1/2 respectively, may shift the balance of cellular signaling in favor of pathways that enhance C9orf114 activity, suggesting that the activity of C9orf114 can be indirectly upregulated by manipulating upstream signaling pathways. Additionally, PMA activates protein kinase C (PKC) which has downstream effects that include the modulation of C9orf114 activity, and SB203580, by inhibiting p38 MAPK, alters signaling dynamics to favor the activation of C9orf114. Collectively, these activators underscore the complex interplay between various signaling molecules and pathways in the regulation of C9orf114 activity, enhancing its functional role within the cell without directly upregulating its expression or through direct activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cAMP analog that activates PKA. The activation of PKA leads to phosphorylation of proteins that may form complexes with C9orf114, thus enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, indirectly enhancing PKA activity and potentially increasing the activity of C9orf114 through phosphorylation pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to downstream effects that promote the activity of C9orf114 through phosphorylation or other post-translational modifications. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases and phosphatases that modulate C9orf114 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is also a calcium ionophore, similar to Ionomycin, and it increases intracellular calcium, which may activate signaling pathways involving C9orf114. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibition properties. It may enhance C9orf114 activity by inhibiting competing signaling pathways, allowing C9orf114-related pathways to be more predominant. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to alterations in the AKT signaling pathway. Inhibition of PI3K may result in the upregulation of compensatory pathways that enhance the activity of C9orf114. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 may shift signaling equilibrium in such a way as to enhance signaling pathways in which C9orf114 is involved. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels, which can activate calcium-dependent signaling pathways involving C9orf114. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may enhance the activity of C9orf114 by reducing competitive signaling and allowing pathways where C9orf114 is active to become more prominent. | ||||||