C7orf72 Activators

Chemical activators of C7orf72 include a variety of compounds that can influence intracellular signaling cascades, thereby leading to the protein's activation. Calcium ionophore A23187 and Ionomycin can increase intracellular calcium levels, which in turn stimulate calcium-dependent kinases. These kinases have the capability to phosphorylate C7orf72, thus activating it. Similarly, Phorbol 12-myristate 13-acetate (PMA) directly activates protein kinase C (PKC), a family of proteins known to phosphorylate a variety of substrates, including C7orf72, signifying its activation. Another compound, Forskolin, elevates cAMP within the cell, which activates protein kinase A (PKA). PKA can then phosphorylate C7orf72, leading to its activation. Furthermore, Okadaic Acid and Calyculin A both inhibit protein phosphatases 1 and 2A, which typically dephosphorylate proteins, thereby maintaining proteins such as C7orf72 in a phosphorylated and active state.

In addition to these, Bisindolylmaleimide I, although typically a PKC inhibitor, can paradoxically activate certain PKC isoforms that may phosphorylate and activate C7orf72. Chelerythrine, also known for selective activation of PKC isoforms, can similarly activate C7orf72 through phosphorylation. Dibutyryl cyclic AMP (dbcAMP), a cell-permeable analog of cAMP, activates PKA, which then contributes to the phosphorylation and subsequent activation of C7orf72. Epigallocatechin Gallate (EGCG) interacts with cellular signaling pathways enabling the activation of kinases that can phosphorylate and activate C7orf72. Anisomycin is recognized for activating MAPK pathways, thereby inducing kinase activity that can lead to the phosphorylation and activation of C7orf72. Lastly, (-)-Blebbistatin can alter myosin II activity and may influence signaling pathways that activate C7orf72. Each of these chemicals, through their unique interactions with cellular signaling molecules and pathways, ensure the phosphorylation and activation of C7orf72, demonstrating a diverse array of mechanisms for regulating its activity.