C7orf47 Inhibitors

The chemical class known as C7orf47 Inhibitors targets a specific protein also known as PPP1R35 (Protein Phosphatase 1 Regulatory Subunit 35). This protein plays a critical role in cellular processes such as centriole duplication and primary cilia assembly. The inhibitors generally act by modulating the activity of protein phosphatases like PP1 and PP2A, which are regulatory proteins that PPP1R35 interacts with. Some compounds, such as Okadaic Acid and Microcystin-LR, inhibit both PP1 and PP2A, thereby having a broader spectrum of phosphatase inhibition. Others, like Fostriecin, are more specific to PP2A. This variability in target specificity adds complexity to the understanding of how these inhibitors function at the molecular level, especially regarding their effect on PPP1R35's roles in centriole elongation and primary cilia assembly.

The mechanisms of action of these inhibitors are not entirely understood, but their impact on protein phosphatases can alter a range of cellular processes. For example, by inhibiting PP1, a compound could interfere with PPP1R35's ability to promote the recruitment of microtubule-binding elongation machinery, thereby affecting centriole to centrosome conversion. Similarly, compounds like Cantharidin and Norcantharidin, which inhibit PP2A, may also influence PPP1R35's regulatory roles, albeit through different phosphatase pathways. Despite these complexities, the general consensus is that C7orf47 inhibitors modulate the phosphatase activities regulated by PPP1R35, thereby affecting its role in critical cellular structures and functions.