C6orf57 Activators
Chemical activators of C6orf57 engage diverse cellular signaling pathways to modulate the protein's activity through phosphorylation. Phorbol 12-myristate 13-acetate (PMA) activates Protein Kinase C (PKC), which can phosphorylate C6orf57, potentially altering its conformation and enhancing its activity. Similarly, Forskolin raises intracellular cAMP, thereby activating Protein Kinase A (PKA) which can then target C6orf57 for phosphorylation. Ionomycin, by increasing intracellular calcium levels, can activate calmodulin-dependent kinases that may also contribute to the phosphorylation state of C6orf57. Hydrogen Peroxide, a reactive oxygen species, can trigger signaling pathways that lead to the phosphorylation of various proteins, including C6orf57, affecting its function. Concurrently, Zinc Pyrithione's ability to activate the MAPK pathway can result in the phosphorylation of C6orf57. Moreover, Calyculin A, by inhibiting protein phosphatases, can lead to an accumulation of phosphorylated proteins, including C6orf57, thereby maintaining the protein in an active state.
Another chemical activator, Thapsigargin, induces endoplasmic reticulum stress which can activate stress-activated protein kinases, and these kinases may phosphorylate C6orf57. Epidermal Growth Factor (EGF) activates its receptor and initiates a cascade that can culminate in the phosphorylation of C6orf57. Similarly, Insulin triggers a kinase cascade that can lead to the phosphorylation and activation of C6orf57. Dibutyryl-cAMP, a cAMP analog, can activate PKA which can subsequently phosphorylate C6orf57. Okadaic Acid, a known phosphatase inhibitor, can result in an elevated phosphorylation state of proteins including C6orf57, ensuring its persistent active state. Finally, A23187, a calcium ionophore, raises intracellular calcium levels which can activate calcium-dependent kinases capable of phosphorylating C6orf57, adding to the spectrum of mechanisms by which C6orf57 can be activated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This compound activates Protein Kinase C (PKC), which is known to phosphorylate a wide array of target proteins. Given C6orf57's cellular role, PKC-mediated phosphorylation can lead to direct activation of C6orf57 by modifying its conformation or interaction with other proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinases known to phosphorylate proteins. The activation of these kinases can result in the phosphorylation and subsequent activation of C6orf57. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
As a reactive oxygen species, Hydrogen Peroxide can activate signaling pathways that lead to the phosphorylation of target proteins, including C6orf57, thereby enhancing its activity through oxidative modification or interaction with other proteins. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can activate the MAPK pathway, which includes kinases that phosphorylate proteins. Activation of MAPK can lead to the phosphorylation of C6orf57, thus activating the protein. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases, leading to an increase in phosphorylated proteins within the cell. This inhibition can prevent the dephosphorylation of C6orf57, maintaining it in an active state. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress, leading to the activation of stress-activated protein kinases. These kinases can phosphorylate C6orf57, resulting in its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin signaling involves a cascade of kinases that can phosphorylate numerous proteins. C6orf57 can be activated by such a kinase cascade, leading to its functional activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
This cAMP analog activates PKA, which is known to phosphorylate various proteins. The activation of PKA can lead to the phosphorylation and activation of C6orf57. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a protein phosphatase inhibitor that can cause an increase in the phosphorylation state of proteins within the cell. This can result in the sustained activation of C6orf57 through phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels, leading to the activation of calcium-dependent kinases. These kinases may phosphorylate and activate C6orf57. | ||||||