C5orf43 Inhibitors
C5orf43 inhibitors represent a diverse class of chemicals that act through various mechanisms to impede the function of the C5orf43 protein. One subset of inhibitors, such as Etoposide and Cisplatin, induces DNA damage, disrupting normal cellular processes and triggering apoptotic pathways. Additionally, compounds like Wortmannin and LY294002 target upstream signaling molecules, inhibiting key kinases like PI3K and affecting the PI3K/Akt/mTOR pathway. Another subset, including Gefitinib and AG-490, interferes with receptor-mediated signaling pathways, disrupting cellular responses vital for proliferation and survival.
Furthermore, inhibitors like PD98059 and U0126 selectively target key kinases within the MAPK/ERK pathway, influencing the signaling cascade associated with cell growth and survival. Staurosporine and SP600125 act as broad-spectrum kinase inhibitors, affecting multiple pathways involved in cell proliferation and apoptosis. Lastly, Rapamycin inhibits C5orf43 through mTOR inhibition, modulating protein synthesis and cellular growth. This diverse range of C5orf43 inhibitors underscores the complex interplay of signaling pathways and cellular processes that converge on this protein, providing potential avenues for exploration.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits C5orf43 by interfering with topoisomerase II activity, disrupting DNA replication, and leading to cell cycle arrest and apoptosis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits C5orf43 through its potent inhibition of phosphatidylinositol 3-kinase (PI3K), a key regulator in cellular signaling cascades affecting protein function. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib inhibits C5orf43 by targeting the epidermal growth factor receptor (EGFR), disrupting downstream signaling pathways involved in cell proliferation and survival. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits C5orf43 via selective inhibition of mitogen-activated protein kinase kinase (MEK), hindering MAPK/ERK signaling and impeding cell growth and survival. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 inhibits C5orf43 by acting as a Janus kinase (JAK) inhibitor, disrupting JAK-STAT signaling pathways crucial for cell proliferation and survival. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits C5orf43 through specific inhibition of phosphoinositide 3-kinase (PI3K), a key enzyme in the PI3K/Akt/mTOR signaling pathway regulating cell growth and survival. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits C5orf43 by targeting p38 mitogen-activated protein kinase (MAPK), modulating inflammatory responses and disrupting cell cycle progression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits C5orf43 through its action as a broad-spectrum kinase inhibitor, affecting multiple signaling pathways and inducing apoptosis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits C5orf43 by targeting c-Jun N-terminal kinase (JNK), disrupting JNK-mediated signaling pathways involved in cell proliferation and apoptosis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits C5orf43 by inhibiting the mammalian target of rapamycin (mTOR), suppressing protein synthesis and cell growth through disruption of mTOR-dependent pathways. | ||||||