C5orf27 Inhibitors
C5orf27 inhibitors employ a multifaceted approach to impede the protein's activity, acting on distinct cellular processes and signaling pathways. These inhibitors are able to alter gene expression by modifying the epigenetic landscape, such as increasing histone acetylation, which leads to the repression of C5orf27 expression. Others target key signaling cascades that C5orf27 is known to participate in, like the mTOR and MAPK pathways, crucial for regulating cell growth, proliferation, and inflammatory responses. By inhibiting mTOR or the downstream kinase p38, these inhibitors manage to decrease the functional activity of C5orf27. Additionally, some inhibitors exert their effects on PI3K/Akt and ERK1/2, pathways known for their roles in cell survival and proliferation, which C5orf27 is also a part of.
These chemical compounds further extend their inhibitory influence on C5orf27 by disrupting cell cycle regulation and protein stability. Inhibitors of aurora kinase interrupt cell division, impacting C5orf27's regulatory role in this process. Proteasome and Hsp90 inhibitors lead to an accumulation of misfolded proteins and the destabilization of clientproteins, which could include C5orf27, thereby reducing its stability and promoting its degradation. The perturbation of ubiquitin-dependent degradation pathways by these inhibitors could also contribute to the downregulation of C5orf27 levels. Furthermore, compounds that impair chaperone functions indirectly affect the correct folding and stability of a wide range of proteins, including C5orf27.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that leads to an increased acetylation state of histones, affecting chromatin structure and gene expression. Overexpression of C5orf27 is repressed due to the altered transcriptional landscape. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that disrupts the mTOR signaling pathway. C5orf27 is downregulated as a result due to its role downstream of mTOR in controlling cell growth and proliferation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that blocks p38-mediated signaling. As C5orf27 operates downstream of p38 in the inflammatory response, its activity is diminished. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that blocks the PI3K/Akt pathway. C5orf27 is implicated in this pathway, and its inhibition leads to the reduced activity of C5orf27 due to decreased Akt-mediated survival signaling. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor that affects cell division processes. C5orf27, involved in cell cycle regulation, experiences reduced function due to the disruption of proper chromosome alignment and segregation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that disrupts the MAPK/ERK pathway, leading to reduced activity of C5orf27, which is implicated in the same pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that leads to the accumulation of ubiquitinated proteins, inducing cell stress and leading to apoptosis. C5orf27, which may be involved in protein degradation pathways, is inhibited by the impaired proteasome function. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
Hsp90 inhibitor that destabilizes client proteins. C5orf27, a client protein of Hsp90, would be destabilized and degraded, leading to its inhibition. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Modulator of the ubiquitin ligase complex, affecting protein degradation. C5orf27 levels are reduced due to altered protein turnover. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog pathway inhibitor that blocks Smoothened signaling. C5orf27 is downregulated as it is part of the cellular response to hedgehog signaling. | ||||||