C5orf25 Inhibitors
SUMO Interacting Motifs Containing 1, abbreviated as "SIMC1," is a protein that is characterized by the presence of SUMO interacting motifs (SIMs). These motifs enable SIMC1 to bind to Small Ubiquitin-like Modifier (SUMO) proteins, which are post-translational modifiers that play a vital role in regulating protein function and localization within the cell.SUMOylation, the process by which SUMO proteins are covalently attached to target proteins, is reversible and dynamic, affecting various aspects of protein stability, interaction, and activity. SIMC1, by virtue of its ability to interact with SUMOylated proteins, is involved in the modulation of SUMO-dependent pathways. The SUMO interaction motifs within SIMC1 allow it to recognize and potentially stabilize SUMO-conjugated substrates, facilitating their involvement in processes such as DNA repair, transcriptional regulation, signal transduction, and nuclear-cytosolic transport.
The function of SIMC1 in these pathways is crucial, as SUMOylation is a key regulatory mechanism for a range of cellular activities. Disruption in SUMO signaling can lead to cellular stress responses and has been associated with various diseases, including cancer and neurodegenerative disorders. By engaging with SUMOylated proteins, SIMC1 can either promote or inhibit their interactions with other cellular components, thereby influencing the outcome of SUMO-mediated regulation.SIMC1's role extends to the maintenance of genomic integrity, where it may assist in the assembly of protein complexes at sites of DNA damage, contributing to effective DNA repair mechanisms. The protein's interaction with SUMOylated factors could also impact chromatin structure and gene expression, by modulating the function of transcription factors and chromatin remodelers.In essence, SIMC1 is a pivotal player in the SUMOylation landscape, with its SUMO interacting motifs allowing it to orchestrate the localization and function of a wide array of proteins, thereby influencing fundamental cellular processes and maintaining cellular homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
A histone acetyltransferase inhibitor that can also influence SUMOylation by affecting the overall chromatin structure and potentially the accessibility of SUMO substrates, indirectly impacting SIMC1 interactions. | ||||||
Ginkgolic acid C15:1 | 22910-60-7 | sc-235249 | 5 mg | $306.00 | 2 | |
Known to inhibit SUMO-activating enzyme (E1), Ginkgolic Acid can reduce SUMOylation levels, potentially affecting the interaction landscape for SIMC1 by altering SUMO conjugation. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
A SIRT1 and SIRT2 inhibitor that indirectly affects SUMOylation through deacetylation pathways, potentially influencing the activity and interactions of SIM-containing proteins like SIMC1. | ||||||
ML-792 | 1644342-14-2 | sc-507423 | 10 mg | $390.00 | ||
A selective SUMO-activating enzyme (E1) inhibitor, ML-792 effectively reduces SUMOylation across the cell, potentially altering the functional context in which SIMC1 operates by decreasing available SUMOylated proteins. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
An inhibitor of dihydrofolate reductase that, while primarily used for its antiparasitic properties, can affect cellular methylation processes and potentially impact SUMOylation and SIMC1 functions indirectly. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can alkalize lysosomes and affect autophagic degradation of proteins, potentially influencing the degradation of SUMOylated proteins and their interaction with SIMC1. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that can disrupt proteasomal and autophagic protein degradation pathways, potentially affecting the turnover of SUMOylated proteins and interactions with SIMC1. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
A quinone methide triterpenoid that induces heat shock response and can affect various cellular stress responses, potentially modulating SUMOylation dynamics and SIMC1's role. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can increase the levels of SUMOylated proteins by preventing their degradation, potentially enhancing the interaction opportunities for SIMC1. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor used in cancer therapy, Bortezomib can indirectly affect SUMOylation by stabilizing SUMOylated proteins, potentially impacting SIMC1 interactions. | ||||||