C330019L16Rik Activators
Zfp976, a zinc finger protein encoded by the Zfp976 gene, emerges as a pivotal player in cellular transcriptional regulation, specifically in response to environmental stressors such as heat. This protein is predicted to possess DNA-binding transcription factor activity, particularly targeting RNA polymerase II cis-regulatory regions. Acting upstream of or within cellular responses to heat, Zfp976 holds a key position in orchestrating gene expression changes that contribute to the adaptive response under stress conditions. The orthologous relationship between Zfp976 and human zinc finger proteins, such as ZNF101 and ZNF699, suggests a conserved role in transcriptional control across species. This evolutionary conservation underscores the functional significance of Zfp976 in cellular processes and highlights its potential as a molecular regulator.
The activation of Zfp976 is a nuanced process influenced by various signaling pathways and molecular interactions. Notably, the modulation of chromatin structure, as exemplified by histone deacetylase inhibitors, creates a permissive environment for Zfp976 activation. Additionally, the protein's responsiveness to signaling pathways like PI3K/AKT, JAK/STAT, and Notch reveals a complex interplay between Zfp976 and key cellular cascades. Indirect activation mechanisms involve the disruption of these pathways, showcasing the intricate nature of Zfp976 regulation. Understanding these activation mechanisms provides valuable insights into the molecular events governing Zfp976 function, emphasizing the importance of a tightly controlled transcriptional response in cellular adaptation to stress. Overall, the detailed exploration of Zfp976 sheds light on its integral role in cellular transcriptional regulation and highlights the intricate network of molecular interactions that govern its activation in response to specific cellular cues.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, activates Zfp976 by promoting an open chromatin structure. Its interaction with HDACs facilitates increased Zfp976 transcriptional activity through histone acetylation, favoring Zfp976's binding to cis-regulatory regions and enhancing its DNA-binding capabilities. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082, an NF-κB inhibitor, regulates Zfp976 through modulation of the NF-κB pathway. By inhibiting NF-κB activity, it influences Zfp976 expression, linking NF-κB signaling to Zfp976 activation. The compound's impact on Zfp976 transcriptional activity is intricately tied to NF-κB pathway modulation, revealing a nuanced regulatory mechanism. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib, a JAK inhibitor, modulates Zfp976 activity through the JAK/STAT pathway. It hampers JAK-mediated phosphorylation, resulting in diminished Zfp976 DNA-binding and transcriptional activity. The compound's interaction with the JAK/STAT pathway exemplifies an indirect activator role, elucidating the targeted modulation of signaling cascades influencing Zfp976 functionality. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT, a γ-secretase inhibitor, regulates Zfp976 through the Notch signaling pathway. By inhibiting Notch activity, it influences Zfp976 expression and DNA-binding capabilities. DAPT's interaction with the Notch pathway reveals a unique mechanism of Zfp976 activation, shedding light on the intricate interplay between Notch signaling and Zfp976-mediated transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
All-trans Retinoic Acid (ATRA), a retinoid, activates Zfp976 by modulating retinoic acid receptors. Its interaction enhances Zfp976 gene transcription, favoring a conducive chromatin environment for Zfp976 activation. The compound's impact on Zfp976 transcriptional activity is linked to retinoic acid receptor-mediated regulation, elucidating a specific mechanism for Zfp976 activation. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42, a JAK2 inhibitor, modulates Zfp976 activity through the JAK/STAT pathway. By inhibiting JAK2-mediated phosphorylation, it leads to diminished Zfp976 DNA-binding and transcriptional activity. The compound's interaction with the JAK/STAT pathway exemplifies an indirect activator role, elucidating the targeted modulation of signaling cascades influencing Zfp976 functionality. | ||||||