C20orf77 Activators
C20orf77 Activators encompass a variety of chemical compounds that, through different signaling pathways, promote the functional activity of the C20orf77 protein. Forskolin and isoproterenol, by increasing intracellular levels of cAMP, activate protein kinase A (PKA), which can phosphorylate substrates potentially interacting with C20orf77, thus enhancing its activity. Similarly, 8-Bromo-cAMP and Dibutyryl cAMP serve as cAMP analogs, directly stimulating PKA and potentially leading to the activation of C20orf77. Oleic acid, by integrating into cellular membranes, may impact membrane-associated proteins and signaling cascades, potentially modifying the functional state of C20orf77. Furthermore, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which has been associated with the regulation of proteins structurally or functionally related to C20orf77, thereby suggesting an enhancement of C20orf77's activity through PKC-mediated modulation.
The activity of C20orf77 is also subject to regulation by lipid signaling molecules and ion concentration changes within the cell. Sphingosine-1-phosphate, a lipid signal, could activate receptors and downstream signaling cascades that would lead to post-translational modifications of C20orf77, enhancing its function. Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium levels, which may trigger calcium-dependent signaling pathways that activate C20orf77. The biochemical landscape regulating C20orf77 is further influenced by small molecule inhibitors such as U0126 and LY294002, which target the MAPK and PI3K/AKT pathways, respectively. These inhibitors might shift the balance of cellular signaling in a way that favors the activation of C20orf77. Wortmannin, another PI3K inhibitor, operates through a similar mechanism, potentially leading to an increase in C20orf77 activity by attenuating competing signals that are downregulated in response to PI3K inhibition. Collectively, these activators, through their targeted effects on various cellular signaling pathways, serve to enhance the functional activity of C20orf77, without necessarily altering its expression levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC has been linked to the regulation of proteins similar to C20orf77, suggesting that PKC-mediated signaling could increase C20orf77 activity through phosphorylation or by altering the cellular localization of C20orf77. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a biologically active lipid that activates sphingosine-1-phosphate receptors, triggering signaling cascades that can regulate proteins like C20orf77. This can lead to an enhanced activity of C20orf77 through post-translational modifications or changes in protein-protein interactions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular Ca2+ concentration. Since Ca2+ signaling is crucial for the function of many proteins, the elevated Ca2+ levels could enhance the activity of C20orf77 by affecting its conformation or interaction with other proteins. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. It can enhance C20orf77 activity by mimicking the effects of cAMP and promoting phosphorylation events that could modify C20orf77 function. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid is a monounsaturated fatty acid that can integrate into cellular membranes, potentially affecting membrane-associated signaling pathways. If C20orf77 associates with membranes, Oleic Acid could alter its activity by changing membrane fluidity or interaction with other membrane proteins. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, leading to alterations in the MAPK pathway. By inhibiting this pathway, U0126 could shift signaling towards pathways that enhance C20orf77 activity, such as those regulated by cAMP. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which affects the AKT signaling pathway. By inhibiting this pathway, it could indirectly enhance C20orf77 activity if C20orf77 is regulated by PI3K/AKT-mediated signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular Ca2+ concentration, potentially enhancing C20orf77 activity through calcium-dependent signaling pathways. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Dibutyryl cAMP is another cell-permeable cAMP analog that activates PKA, potentially enhancing C20orf77 activity by promoting phosphorylation events. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. By blocking PI3K, it may enhance C20orf77 activity if C20orf77's function is modulated by signals downstream of PI3K. | ||||||