C20orf54 Inhibitors
The inhibitors listed are primarily focused on targeting folate metabolism and absorption, which are processes directly related to the function of SLC46A1/C20orf54. By influencing these pathways, they may indirectly affect the functionality of this folate transporter. Methotrexate, Trimethoprim, and Pyrimethamine are dihydrofolate reductase inhibitors. They affect folate metabolism, potentially impacting the transport function of SLC46A1, as it is closely linked to the cellular folate levels and metabolism. Pemetrexed and Raltitrexed, which target folate-dependent enzymes like thymidylate synthase, can indirectly affect the demand for folate transport, possibly impacting SLC46A1 functionality.
Sulfamethoxazole, a sulfonamide antibiotic, and Sulfasalazine, used in inflammatory bowel diseases, inhibit folate synthesis, which could indirectly affect SLC46A1-mediated folate transport. Proton Pump Inhibitors like Omeprazole may alter intestinal pH, which can influence the intestinal absorption of folate, thereby potentially impacting the function of SLC46A1. Levamisole and Zidovudine impact folate metabolism and absorption. Their effects could extend to modifying the interaction between folate and SLC46A1. Phenytoin and Glucocorticoids like Prednisone are known to interfere with various aspects of cellular metabolism, including folate utilization. Their use might indirectly influence SLC46A1's transport activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
An antifolate compund that inhibits dihydrofolate reductase, potentially impacting folate transport and metabolism. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $66.00 $158.00 $204.00 $707.00 $3334.00 | 4 | |
A dihydrofolate reductase inhibitor, potentially affecting folate absorption and SLC46A1 functionality. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Another dihydrofolate reductase inhibitor, potentially influencing folate transport mediated by SLC46A1. | ||||||
Pemetrexed Disodium | 150399-23-8 | sc-219564 | 10 mg | $133.00 | 5 | |
An antifolate agent, potentially affecting folate transport processes. | ||||||
Raltitrexed | 112887-68-0 | sc-219933 | 10 mg | $143.00 | ||
An inhibitor of thymidylate synthase, indirectly affecting folate metabolism and possibly SLC46A1 function. | ||||||
Sulfamethoxazole | 723-46-6 | sc-208405 sc-208405A sc-208405B sc-208405C | 10 g 25 g 50 g 100 g | $36.00 $54.00 $68.00 $107.00 | 5 | |
A sulfonamide agent that inhibits folate synthesis, potentially impacting SLC46A1-related transport. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
May affect intestinal pH, indirectly influencing folate absorption and SLC46A1 activity. | ||||||
Levamisole Hydrochloride | 16595-80-5 | sc-205730 sc-205730A | 5 g 10 g | $42.00 $67.00 | 18 | |
An immunomodulator that can affect folate metabolism, potentially influencing SLC46A1. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
A compound that can impact folate metabolism and absorption, potentially affecting SLC46A1. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
An agent that may interfere with folate metabolism, possibly impacting SLC46A1 functionality. | ||||||