Date published: 2026-1-11

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C20orf46 Inhibitors

Transmembrane Protein 74B, often abbreviated as TMEM74B, is a protein that is embedded in the membrane of eukaryotic cells. Its transmembrane nature indicates that it spans the entire lipid bilayer, allowing it to participate in various cellular processes that require interactions between the intracellular and extracellular environments.The precise function of TMEM74B is not fully characterized, but proteins in the TMEM family typically play roles in processes such as signaling, transport, and cellular homeostasis. TMEM74B, with its transmembrane domains, is likely involved in the regulation of substances entering and leaving the cell, or in the transmission of signals from the outside to the inside of the cell.

In terms of structure, TMEM74B consists of several hydrophobic segments that allow it to integrate into the lipid-rich environment of the cell membrane. These segments are connected by hydrophilic loops that may protrude into the intracellular or extracellular space, potentially serving as sites for protein-protein interactions or for the recognition of specific molecules.Research on TMEM74B and related proteins suggests they may have roles in cellular growth, apoptosis, and autophagy. These processes are critical for the maintenance of cellular health, the response to stress, and the regulation of cell death. TMEM74B could be involved in the intricate balance of these processes, although the mechanisms by which it influences them remain to be elucidated.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin is an mTOR inhibitor, affecting cell growth and proliferation pathways that might intersect with TMEM74B functions.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor, involved in key signaling pathways related to cell survival and proliferation.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is a MEK1/2 inhibitor, affecting the MAPK/ERK signaling pathway, which could be relevant to TMEM74B.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin inhibits phosphoinositide 3-kinases (PI3K), impacting various cellular processes potentially related to TMEM74B.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059 specifically inhibits MEK in the MAPK/ERK pathway, involved in cell differentiation and proliferation.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor, impacting stress-related cellular pathways and inflammatory responses.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 inhibits JNK, involved in apoptosis, inflammation, and cellular differentiation.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib is a proteasome inhibitor, affecting multiple signaling pathways and protein degradation.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 inhibits the proteasome, leading to accumulation of proteins and affecting cell cycle and apoptosis.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin inhibits SERCA, affecting calcium homeostasis, potentially relevant to TMEM74B's function.