C17orf28 Activators
Compounds such as Rolipram, Genistein, and SB203580 specifically target different kinases or enzymes like PDE4, tyrosine kinases, and p38 MAPK, respectively. These interactions can lead to a cascade of intracellular events that can modulate the phosphorylation state of proteins, which in turn can alter their function. MG132's inhibition of proteasomal degradation can lead to an accumulation of proteins, potentially affecting the protein turnover rate and steady-state levels within the cell.
KN-93, PD0325901, U0126, and ZM-447439 target key regulatory enzymes such as CaMKII, MEK, and Aurora kinase, which are integral parts of calcium signaling, MAPK/ERK pathway, and cell division regulation. These pathways are crucial for the control of protein activity and cellular responses to various stimuli. LY294002 and SP600125 act on the PI3K/AKT and JNK pathways, respectively, influencing processes such as cell survival, proliferation, and stress responses. Y-27632 and AICAR, through their inhibition of ROCK and activation of AMPK, can affect cytoskeletal organization and energy metabolism. These activities can result in widespread effects on cellular function, including alterations in the activity of a broad range of proteins.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibits phosphodiesterase 4 (PDE4), leading to increased cAMP levels which can activate PKA and potentially influence proteins regulated by PKA-dependent phosphorylation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits protein tyrosine kinases, which can modulate phosphorylation states and subsequently alter protein activities within these signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase, which can affect the MAPK pathway and potentially alter the activity of proteins regulated by p38 MAPK-mediated phosphorylation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Inhibits the proteasome, which can lead to increased levels of proteins by preventing their degradation and potentially influence proteins regulated by proteasomal degradation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII), which can affect calcium signaling pathways and potentially influence proteins regulated by CaMKII-mediated phosphorylation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK1/2, which can affect the MAPK/ERK pathway and potentially alter the activity of proteins regulated by MEK1/2-mediated phosphorylation. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Inhibits Aurora kinase, which can affect cell cycle regulation and potentially influence proteins involved in cell division and checkpoint control. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which can modulate the AKT signaling pathway and potentially affect the activity of proteins regulated by AKT phosphorylation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which can affect the MAPK pathway and potentially alter the activity of proteins regulated by JNK-mediated phosphorylation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK, which can affect cytoskeletal dynamics and potentially influence proteins involved in cell shape and motility. | ||||||