C14orf79 Inhibitors
Inhibitors of C14orf79 operate through various biochemical pathways to decrease the functional activity of this protein. One class of inhibitors works by altering the chromatin structure and gene expression, affecting the accessibility of C14orf79 to DNA and thus reducing its activity. Another group targets phosphorylation-dependent signaling pathways, which C14orf79 may be involved in either as a regulator or as a downstream effector. For example, the inhibition of kinase activity can disrupt these pathways, leading to a reduction in C14orf79's regulatory influence. Additionally, the inhibition of the PI3K/AKT and MAPK/ERK pathways represents a strategy that indirectly suppresses C14orf79 activity by diminishing the signaling cascades it is potentially connected with.
Further mechanisms of inhibition include the obstruction of the mTOR pathway which is implicated in cell growth and proliferation where C14orf79 could play a role. Proteasome inhibitors also contribute to the modulation of C14orf79 function by preventing the degradation of proteins, including C14orf79 itself, thereby affecting its turnover and stability. Inhibition of other kinases like JNK and Aurora kinase, which are involved in apoptotic and cell cycle progression pathways, can lead to decreased C14orf79 function by impeding processes that C14orf79 may influence.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor impacts chromatin structure and gene expression. C14orf79, involved in chromatin organization, is inhibited as tighter chromatin structure reduces its accessibility to DNA. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that targets a wide range of kinases. It indirectly inhibits C14orf79 by disrupting phosphorylation-dependent signaling pathways that C14orf79 may regulate or be regulated by. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K, it downregulates the PI3K/AKT pathway. Given C14orf79's interaction with this pathway, inhibition of PI3K leads to decreased C14orf79-mediated signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which is part of the regulatory pathway that affects cell growth and proliferation. C14orf79, involved in these processes, is inhibited due to mTOR pathway suppression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that indirectly affects C14orf79 by altering the MAPK/ERK pathway, impacting processes where C14orf79 is a regulatory component. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This compound is a p38 MAPK inhibitor, which could alter the stress response signaling. C14orf79, associated with this pathway, would have diminished activity due to the inhibition of p38 MAPK. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that prevents the degradation of protein substrates, including C14orf79, thereby affecting its turnover and function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
This compound inhibits PI3K, leading to a reduction in the PI3K/AKT signaling pathway, which may involve C14orf79 activity regulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which modulates apoptotic and growth pathways that C14orf79 might be a part of, leading to lowered function of C14orf79 due to inhibited JNK activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
A selective Aurora kinase inhibitor that may affect cell cycle progression. C14orf79, implicated in cell cycle control, would be inhibited by disruption of Aurora kinase activity. | ||||||