C14orf73 Inhibitors
Inhibitors of C14orf73 leverage various strategies to decrease its activity within the cell. Blocking the ATP binding sites of protein kinases with specific inhibitors could impede the phosphorylation activity of C14orf73, assuming it participates in kinase signaling. This blockade could restrict C14orf73's ability to modulate other proteins and execute its biological functions. Furthermore, the inhibition of key signaling molecules such as PI3K and MEK1/2 has a cascade effect; given C14orf73 is implicated in the PI3K/Akt or the MAPK/ERK pathways, the dampening of these pathways would result in the indirect reduction of C14orf73 activity. This could manifest as a lower propensity for C14orf73 to engage in pathways critical for cell proliferation and survival if it is indeed a component of these signaling cascades.
Inhibitors that target mTOR could indirectly diminish C14orf73 activity by throttling protein synthesis, which may be vital if C14orf73 is involved in growth signaling processes. Other inhibitors focus on stress response pathways, such as those mediated by p38 MAPK; assuming C14orf73 is modulated by stress-activated pathways, the disruption of p38 signaling would indirectly suppress its function. Similarly, curbing JNK activity could lead to the indirect inhibition of C14orf73 as it is associated with JNK-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This compound is a histone deacetylase inhibitor that can alter chromatin structure and gene expression. In the context of C14orf73, this alteration can lead to a change in the expression of genes that are co-regulated with C14orf73, thereby indirectly inhibiting its function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, it changes DNA methylation patterns which can suppress the expression of genes including those that are functionally connected to C14orf73, reducing its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, Rapamycin impacts cell growth and proliferation pathways that are linked to the biological processes C14orf73 is involved in, thus indirectly inhibiting its activity by diminishing cellular resources necessary for its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that disrupts the PI3K/Akt pathway, leading to altered cell survival and metabolism. This disruption can reduce the metabolic capacity of cells to support the function of proteins such as C14orf73. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By inhibiting MEK, which is part of the MAPK pathway, PD98059 indirectly affects the phosphorylation status of proteins associated with C14orf73, inhibiting its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This p38 MAPK inhibitor can prevent the activation of this specific MAPK pathway, leading to decreased regulation of proteins that interact with or modify the activity of C14orf73. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, SP600125 can alter the JNK signaling pathway, which can affect the functional state of C14orf73 by modifying the cellular response to stress, which C14orf73 might be involved in. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to an accumulation of proteins destined for degradation. This buildup can affect protein turnover rates, including those in pathways where C14orf73 is active, indirectly inhibiting its function. | ||||||
WZ 4002 | 1213269-23-8 | sc-364655 sc-364655A | 10 mg 50 mg | $180.00 $744.00 | 1 | |
A selective inhibitor of EGFR mutations, WZ 4002 can impact cell signaling pathways that might involve C14orf73, leading to a downstream reduction in its activity. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
An inhibitor of the RAF kinase, ZM 336372 can affect the MAPK pathway, leading to an indirect decrease in the activity of proteins that are in the same pathway or are regulated by the pathway, such as C14orf73. | ||||||