C14orf48 Inhibitors
C14orf48 inhibitors encompass a diverse array of compounds that exert their effects through the interruption of specific signaling pathways and biochemical processes. These inhibitors target key regulatory mechanisms that are essential for the functional activity of C14orf48, leading to its inhibition. For instance, certain inhibitors in this group obstruct kinase signaling cascades that are potentially crucial for the phosphorylation state of C14orf48, which is a pivotal modulator of its activity. The disruption of these pathways ensures that C14orf48 does not undergo the necessary phosphorylation, thereby inhibiting its activity. Moreover, some compounds specifically target the PI3K/Akt and MAPK/ERK pathways, which are often integral to the regulation of proteins. By blocking the activity of these signaling molecules, the inhibitors preclude the transmission of signals that might be necessary for C14orf48 to exert its cellular functions.
Additionally, other inhibitors in the selection act by inhibiting the mTOR signaling pathways, potentially affecting C14orf48 activity due to the pathway's role in regulating cell growth and metabolism, which could be critical for C14orf48's function. Proteasome inhibitors also play a role in inhibiting C14orf48, albeit via a different mechanism. They increase the accumulation of ubiquitinated proteins, which could include C14orf48 if it is subject to regulation by ubiquitination. This accumulation can lead to a decrease in functional C14orf48 due to the presence of ubiquitin tags that are normally a signal for protein degradation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can disrupt protein phosphorylation processes. Since C14orf48 might be regulated by phosphorylation, staurosporine would inhibit C14orf48 by preventing its phosphorylation state changes necessary for its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that disrupts the PI3K/Akt signaling pathway. Assuming C14orf48 activity is regulated by this pathway, inhibition of PI3K would lead to reduced activity of C14orf48 due to lower Akt-mediated regulatory phosphorylation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor that blocks the MAPK/ERK pathway. Assuming C14orf48 is a downstream effector of this pathway, inhibition of MEK would result in decreased activation of ERK and subsequent reduction in C14orf48 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor. By inhibiting p38, this compound would lead to a reduction in C14orf48 activity given C14orf48 is involved in the p38 MAPK stress response signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which affects the mTORC1 and mTORC2 complexes. Assuming C14orf48 is involved in mTOR signaling, rapamycin would lead to a decrease in C14orf48 activity by inhibiting mTOR-dependent signal transduction. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, which would decrease the activity of C14orf48 by inhibiting the PI3K/Akt pathway, assuming C14orf48 is regulated by this signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that would decrease C14orf48 activity by inhibiting the JNK signaling pathway, which could regulate the activity of C14orf48. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor that could reduce the activity of C14orf48 by inhibiting Src family kinase-dependent signaling pathways that regulate C14orf48's function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to increased levels of ubiquitinated proteins. Assuming C14orf48 is regulated via ubiquitination, bortezomib would inhibit its degradation, potentially leading to reduced functional activity due to accumulation of non-functional ubiquitinated C14orf48. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Another proteasome inhibitor that prevents the degradation of ubiquitin-conjugated proteins. MG132 would inhibit C14orf48 activity given C14orf48 is regulated by ubiquitination. | ||||||